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Usage

Uses

Used in Dye and Pigment Production:
2-(Aminomethyl)-4-chloroaniline is utilized as a key intermediate in the synthesis of dyes and pigments, contributing to the coloration and stability of these products in various applications.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2-(Aminomethyl)-4-chloroaniline serves as a building block for the development of new drugs, leveraging its chemical properties to create compounds with specific therapeutic effects.
Used in Agrochemical Production:
2-(Aminomethyl)-4-chloroaniline is also employed in the creation of agrochemicals, where it plays a role in the synthesis of products designed to protect crops and enhance agricultural yields.
Safety Considerations:
Given its classification as a hazardous substance, it is imperative to adhere to proper safety protocols when handling, storing, and using 2-(Aminomethyl)-4-chloroaniline to minimize the risk of exposure and potential harm to individuals and the environment.

Upstream product

• 61272-77-3 2-cyano-4-fluoroaniline 

Downstream Products

• 1399327-71-9 6-fluoro-2-phenylquinazoline 
• 1222094-46-3 2-(4-chlorophenyl)-5-fluoroquinazoline 
• 1399327-76-4 6-fluoro-2-(4-chlorophenyl)quinazoline 

Relevant academic research and scientific papers

Base-Promoted Synthesis of 2-Aryl Quinazolines from 2-Aminobenzylamines in Water

A transition-metal-free procedure for the synthesis of a highly valuable class of heteroaromatics, quinazolines, was developed by using easily available 2-aminobenzylamines and α,α,α-trihalotoluenes. The transformation proceeded smoothly in the presence of only sodium hydroxide and molecular oxygen in water at 100 °C, furnishing a variety of 2-aryl quinazolines. The crystallization process of the crude reaction mixture for the purification of the solid products circumvents huge solvent-consuming workup and column chromatographic techniques, which make the overall process more sustainable and economical.

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.