7717-13-7Relevant academic research and scientific papers
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease
Bai, Ping,Wang, Keren,Zhang, Pengfei,Shi, Jian,Cheng, Xinfeng,Zhang, Qi,Zheng, Cheng,Cheng, Yao,Yang, Jian,Lu, Xiaoxia,Sang, Zhipei
, (2019)
A series of novel chalcone-O-alkylamine derivatives were designed, synthesized and evaluated as multifunctional anti-Alzheimer's disease agents. Based on the experimental results, compound 23c exhibited good inhibitory potency on both acetylcholinesterase
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease
Zhu, Gaofeng,Wang, Keren,Shi, Jian,Zhang, Pengfei,Yang, Dan,Fan, Xiaotian,Zhang, Ziyi,Liu, Wenmin,Sang, Zhipei
supporting information, (2019/08/26)
A series of 2-acetylphenol-donepezil hybrids was designed and synthesized based on multi-target-directed ligands strategy. The biological activities were evaluated by AChE/BChE inhibition and MAO-A/MAO-B inhibition. The results revealed that the tertiary
