77179-30-7Relevant academic research and scientific papers
Synthesis method and uses of natural product Xanthohumol D and analogue thereof
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, (2019/12/31)
The invention discloses a synthesis method and uses of a natural product Xanthohumol D (I) and an analogue (II) thereof, wherein the structural formula is defined the specification, the novel isopentenyl chalcone compound is obtained, and Xanthohumol D has good inhibitory activity on bacillus subtilis. According to the invention, the preparation method has advantages of few process steps and easily available raw materials, and is suitable for industrial production.
Mallotojaponins B and C: Total Synthesis, Antiparasitic Evaluation, and Preliminary SAR Studies
Grayfer, Tatyana D.,Grellier, Philippe,Mouray, Elisabeth,Dodd, Robert H.,Dubois, Jo?lle,Cariou, Kevin
supporting information, p. 708 - 711 (2016/03/01)
(Chemical Equation Presented). The first total syntheses of mallotojaponin B and C as well as several analogues have been achieved. Biological evaluation of the synthesized compounds against Plasmodium falciparum and Trypanosoma brucei have also been carried out.
Synthesis and Antimalarial Activity of Mallatojaponin C and Related Compounds
Eaton, Alexander L.,Dalal, Seema,Cassera, M. Belen,Zhao, Shuqi,Kingston, David G. I.
, p. 1679 - 1683 (2016/07/06)
The phloroglucinol mallotojaponin C (1) from Mallotus oppositifolius, which was previously shown by us to have both antiplasmodial and cytocidal activities against the malaria parasite Plasmodium falciparum, was synthesized in three steps from 2′,4′,6′-tr
Natural and non-natural prenylated chalcones: Synthesis, cytotoxicity and anti-oxidative activity
Vogel, Susanne,Ohmayer, Susanne,Brunner, Gabi,Heilmann, Joerg
, p. 4286 - 4293 (2008/12/20)
A general strategy for the synthesis of 3′-prenylated chalcones was established and a series of prenylated hydroxychalcones, including the hop (Humulus lupulus L.) secondary metabolites xanthohumol (1), desmethylxanthohumol (2), xanthogalenol (3), and 4-methylxanthohumol (4) were synthesized. The influence of the A-ring hydroxylation pattern on the cytotoxic activity of the prenylated chalcones was investigated in a HeLa cell line and revealed that non-natural prenylated chalcones, like 2′,3,4′,5-tetrahydroxy-6′-methoxy-3′-prenylchalcone (9, IC50 3.2 ± 0.4 μM) as well as the phase 1 metabolite of xanthohumol (1), 3-hydroxyxanthohumol (8, IC50 2.5 ± 0.5 μM), were more active in comparison to 1 (IC50 9.4 ± 1.4 μM). A comparison of the cytotoxic activity of xanthohumol (1) and 3-hydroxyxanthohumol (8) with the non-prenylated analogs helichrysetin (12, IC50 5.2 ± 0.8) and 3-hydroxyhelichrysetin (13, IC50 14.8 ± 2.1) showed that the prenyl side chain at C-3′ has an influence on the cytotoxicity against HeLa cells only for the dihydroxylated derivative. This offers interesting synthetic possibilities for the development of more potent compounds. The ORAC activity of the synthesized compounds was also investigated and revealed the highest activity for compounds 12, 4′-methylxanthohumol (4), and desmethylxanthohumol (2), with 4.4 ± 0.6, 3.8 ± 0.4, and 3.8 ± 0.5 Trolox equivalents, respectively.
Synthesis of amoradicin
Hossain, M. Amzad,Salehuddin
, p. 2399 - 2401 (2007/10/03)
Amoradicin 6, a constituent of the stems of Paramignya griffithii (Rutaceae) has been synthesised following an unambiguous route. All the new products have been characterised on the basis of spectral data and microanalysis.
SYNTHESIS OF HELICHROMANOCHALKONE AND ISOXANTHOHUMOL
Sharma, V. K.,Gupta, S. R.
, p. 93 - 96 (2007/10/02)
Synthesis of helichromanochalkone (1) and isoxanthohumol (2), the constituents of Helichrysum cymosum ssp. calvum and Helychrysum tenuiculum, respectively, have been achieved to provide confirmation for the structures proposed for the two new natural products.
