77180-89-3

Upstream product

• 41545-90-8 1-(O³,O⁵-dibenzoyl-α-L-erythro-2-deoxy-pentofuranosyl)-1H-pyrimidine-2,4-dione 
• 1005-56-7 phenylcarbonochloridothioate 
• 265988-67-8 1-(3,5-di-O-benzoyl-β-L-xylofuranosyl)-5-fluorouracil 
• 265988-66-7 1-(2-O-acetyl-3,5-di-O-benzoyl-β-L-xylofuranosyl)-5-fluorouracil 

Downstream Products

• 725259-06-3 C₂₃H₁₉FN₂O₆S 
• 374107-75-2 1-(2-deoxy-5-O-benzoyl-β-L-threo-pentofuranosyl)-5-fluorouracil 
• 77180-98-4 1-(2-deoxy-3,5-di-O-benzoyl-β-L-erythro-pentofuranosyl)-5-fluorouracil 
• 265988-68-9 C₂₃H₁₉FN₂O₆S 

Relevant academic research and scientific papers

β-L nucleosides for the treatment of HIV infection

Compounds and pharmaceutical compositions active against HIV are provided, as is a method for the treatment of HIV infection in humans and other host animals is provided comprising administering an effective amount of a β-L-(2′ or 3′-azido)-2′,3′-dideoxy-

Stereospecific synthesis and biological evaluations of β-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine

In the search for new chemotherapeutic agents, we have focused our work on the synthesis and the study of several unnatural β-L-nucleoside analogues. In this paper, we report on the synthesis of β-L-pentofuranonucleosides (and their 2′-deoxy derivatives) of 5-fluorouracil and their inhibitory effects on the proliferation of several murine and human tumor cells. The corresponding 5-fluorocytosine derivatives were also synthesized and their anti-HIV and anti-HBV activities have been evaluated.