77180-98-4

Upstream product

• 41545-90-8 1-(O³,O⁵-dibenzoyl-α-L-erythro-2-deoxy-pentofuranosyl)-1H-pyrimidine-2,4-dione 
• 65-85-0 benzoic acid 
• 374107-75-2 1-(2-deoxy-5-O-benzoyl-β-L-threo-pentofuranosyl)-5-fluorouracil 
• 51-21-8 5-fluorouracil 
• 51785-70-7 methyl 3,5-di-O-benzoyl-2-deoxy-L-erythro-pentofuranoside 
• 265988-67-8 1-(3,5-di-O-benzoyl-β-L-xylofuranosyl)-5-fluorouracil 
• 77180-89-3 1-(2-deoxy-3,5-di-O-benzoyl-β-L-threo-pentofuranosyl)-5-fluorouracil 
• 169527-98-4 1-(2-deoxy-β-L-threo-pentofuranosyl)-5-fluorouracil 
• 17242-85-2 5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine 
• 31615-99-3 3',5'-dibenzoyl-2'-deoxy-β-L-uridine 
• 265988-66-7 1-(2-O-acetyl-3,5-di-O-benzoyl-β-L-xylofuranosyl)-5-fluorouracil 

Downstream Products

• 725259-06-3 C₂₃H₁₉FN₂O₆S 
• 181785-84-2 elvucitabine 

Relevant academic research and scientific papers

NOVEL 3′-DEOXY-3′-METHYLIDENE- -L-NUCLEOSIDES

The present invention includes novel 3′-deoxy-3′-methylidene-β-L-nucleosides, pharmaceutical composition comprising such compounds, as well as the methods to treat or to prevent viral infections and in particular HBV and/or HIV infections. In accordance with the present invention, there are provided compounds represented by Formula (I), wherein B is selected from A1 and A2;

Stereospecific synthesis and biological evaluations of β-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine

In the search for new chemotherapeutic agents, we have focused our work on the synthesis and the study of several unnatural β-L-nucleoside analogues. In this paper, we report on the synthesis of β-L-pentofuranonucleosides (and their 2′-deoxy derivatives) of 5-fluorouracil and their inhibitory effects on the proliferation of several murine and human tumor cells. The corresponding 5-fluorocytosine derivatives were also synthesized and their anti-HIV and anti-HBV activities have been evaluated.