77182-96-8

Upstream product

• 148904-74-9 2-[(E)-3-(4-Chloro-phenyl)-2-methyl-allylidene]-malonic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 18795-82-9 2-propylidene malonic acid dimethyl ester 

Downstream Products

• 77182-97-9 (2E,4E)-5-(4-Chloro-phenyl)-4-methyl-penta-2,4-dienoic acid 

Relevant academic research and scientific papers

A tentative descriptive modelling of chemical structure-biological activity relationships. Biological evaluation of a series of polyethylenic acids

48 new polyethylenic-malonic acids have been submitted to an antimicrobial and antifungal screening. After a suitable recoding, the experimental results were analyzed according to two mathematical multivariate analysis using a computer process i.e. Correspondence Factorial Analysis and Cluster Analysis. These methods allowed an accurate study of the structure of the system and a thorough investigation of the structure-activity-specificity relationships. On the other side, magnitude and/or specificity of the observed biological effects were related to structural features. These results should be useful in order to elaborate synthetic strategies.