77182-97-9Relevant academic research and scientific papers
Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides
Marson, Charles M.,Serradji, Nawal,Rioja, Alphonso S.,Gastaud, Sebastien P.,Alao, John P.,Coombes, R. Charles,Vigushin, David M.
, p. 2477 - 2481 (2004)
Syntheses of (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides are described, some of which are potent inhibitors of histone deacetylase, a double bond conferring more than a 10-fold increase in potency compared with the triple bond analogue oxamflatin.
A tentative descriptive modelling of chemical structure-biological activity relationships. Biological evaluation of a series of polyethylenic acids
Valla,Giraud,Dore
, p. 295 - 301 (2007/10/02)
48 new polyethylenic-malonic acids have been submitted to an antimicrobial and antifungal screening. After a suitable recoding, the experimental results were analyzed according to two mathematical multivariate analysis using a computer process i.e. Correspondence Factorial Analysis and Cluster Analysis. These methods allowed an accurate study of the structure of the system and a thorough investigation of the structure-activity-specificity relationships. On the other side, magnitude and/or specificity of the observed biological effects were related to structural features. These results should be useful in order to elaborate synthetic strategies.
