77197-87-6Relevant academic research and scientific papers
Pyrimido?5,4-D!pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
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, (2008/06/13)
The present invention relates to pyrimido?5,4-d!pyrimidines of the general formula STR1 in which Ra to Rc are as defined herein, their tautomers, their stereoisomers and their salts, in particular their physiologically tolerated salts with inorganic or organic acids or bases which have valuable pharmacological properties, in particular an inhibiting action on signal transduction mediated by tyrosine kinases, their use for the treatment of diseases, in particular tumor diseases.
SUBSTITUTION OF THE CARBOXYL GROUP BY BROMINE IN PHENYLCYCLOPROPANECARBOXYLIC ACIDS
Sychkova, L. D.,Shabarov, Yu. S.
, p. 1775 - 1779 (2007/10/02)
The substitution of the carboxyl group by bromine in isomeric phenylcyclopropanecarboxylic acids and their noncyclic analog 2-methyl-2-phenylpropionic acid was investigated.The direction of the reaction depends significantly on the nature of the solvent, the temperature, and the mutual arrangement of the phenyl radical and the carboxyl group.A new preparative method was developed for the synthesis of 1-phenyl-1-cyclopropanecarboxylic acid.
