77198-63-1

Upstream product

• 2826-22-4 4-fluorobenzylidenemalononitrile 
• 108-94-1 cyclohexanone 
• 109-77-3 malononitrile 
• 459-57-4 4-fluorobenzaldehyde 
• 77198-44-8 2-amino-4-(4-fluorophenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile 

Relevant academic research and scientific papers

Efficient NaOH-catalyzed reaction of aromatic aldehyde, cyclic ketones, and malononitrile under solvent-free conditions using a grinding method

An efficient and facile synthesis of 2,6-dicyanoanilines via a one-pot reaction of aromatic aldehydes, malononitrile, and cyclic ketones in the presence of NaOH under solvent-free conditions using a grinding method has been developed. Compared with the classical reaction conditions, the new synthetic method has the advantages of excellent yields, shorter reaction times, and mild reaction conditions. Copyright Taylor & Francis Group, LLC.

CYCLIZATION REACTIONS OF NITRILES. III. SYNTHESIS OF o-CYANOANILINES BY THE THORPE REACTION

The reaction of alkylidenemalononitriles with arylidene derivatives of malononitrile and cyanoacetic ester leads to the formation of derivatives of 1-amino-2,6-dicyano-3,5-diaryl-1,3-cyclohexadiene or 2,4-dicyano-3-amino-5-arylbicyclodeca-2,10-dien