2826-22-4

Usage

Uses

Used in Organic Synthesis:
2-(4-Fluorobenzylidene)-malononitrile is used as a versatile building block for the synthesis of various bioactive molecules, including pharmaceuticals and agrochemicals. Its ability to undergo a wide range of chemical reactions makes it a valuable and versatile tool in the development of new chemical compounds.
Used in Medicinal Chemistry:
2-(4-Fluorobenzylidene)-malononitrile is used as a reagent in medicinal chemistry for the development of new pharmaceutical compounds. Its unique structure and properties make it a valuable tool for a variety of chemical transformations, contributing to the discovery and synthesis of novel therapeutic agents.

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 109-77-3 malononitrile 
• 670-54-2 ethenetetracarbonitrile 
• 98-86-2 acetophenone 
• 32691-93-3 α,α-dimethoxy-4-fluorotoluene 
• 459-56-3 4-fluorobenzylic alcohol 
• 5676-81-3 4-fluorobenzalaniline 

Downstream Products

• 125219-59-2 N-methylmorpholinium 6-amino-4-(4-fluorophenyl)-3,5-dicyano-2-pyridinethiolate 
• 82127-03-5 3-(4-fluorophenyl-3-oxo-1-(2-thienyl)propyl)propanedinitrile 
• 71945-85-2 2-Amino-6-(4-fluoro-phenyl)-4-phenyl-cyclohexa-2,4-diene-1,1,3-tricarbonitrile 
• 94638-86-5 4-(4-Fluoro-phenyl)-5,6-dimethyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 136494-58-1 4-Cyclopropyl-6-(4-fluoro-phenyl)-2-imino-cyclohex-3-ene-1,1,3-tricarbonitrile 
• 111861-35-9 2-Amino-4-(4-fluoro-phenyl)-6-hexyl-7-hydroxy-4H-chromene-3-carbonitrile 
• 127458-37-1 2,2-Dicyano-3-(4-fluoro-phenyl)-cyclopropanecarboxylic acid amide 
• 127458-41-7 1,1-dicyano-3-(1-pyridino)-2-(4-fluorophenyl)-3-cyclopropanyl-1-propanide 
• 133829-02-4 C₁₈H₁₅FN₄O 
• 133828-91-8 (2S,3S,8aR)-1,1,6-Tricyano-2-(4-fluoro-phenyl)-1,2,3,8a-tetrahydro-indolizine-3-carboxylic acid amide 
• 77198-63-1 2-amino-4-(4-fluorophenyl)-5,6,7,8-tetrahydronaphthalene-1,3-dicarbonitrile 
• 94639-17-5 4-(4-Fluoro-phenyl)-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 94639-08-4 6-Amino-4-(4-fluoro-phenyl)-2,2-dimethyl-4H-[1,3]dithiine-5-carbonitrile 
• 89607-54-5 2-[(4-Fluoro-phenyl)-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)-methyl]-malononitrile 

Relevant academic research and scientific papers

Synthesis and anticancer activity of novel tetrahydroquinoline and tetrahydropyrimidoquinoline derivatives

A series of new tetrahydroquinolines with different substituents at C-2 and C-4 positions in addition to several tetrahydropyrimidoquinolin-4-amines and tetrahydropyrimidoquinoline-2,4-diamines were synthesized. The in vitro anticancer activity of all new

Seven new Zn(II)/Cd(II) coordination polymers with 2-(hydroxymethyl)-1H-benzo[d]imidazole-5-carboxylic acid: Synthesis, structures and properties

Using a new simi-rigid multitopic ligand 2-(hydroxymethyl)-1H-benzo[d]imidazole-5-carboxylic acid (H2L), seven new coordination polymers [Zn3(L)2(μ2-OH)2]n (1), {[Zn2(HL)2/

Catalyst-free one-pot synthesis and antioxidant evaluation of highly functionalized novel 1,4-dihydropyridine derivatives

A catalyst-free greener protocol for the most effective one-pot synthesis of 2,6-diamino-4-aryl-1-propyl/cyclohexyl-1,4-dihydropyridine-3,5-dicarbonitrile derivatives has been developed using a simple three-component reaction of structurally diverse aldeh

Metal-free multicomponent synthesis of novel macrocyclic tetrathiadienes with cyano and amino groups

The first synthesis of 5,12-diamino-7,14-bis(aryl)-1,4,8,11-tetrathiacyclotetradeca-5,12-diene-6,13-dicarbonitriles was performed as a multicomponent macroheterocyclization of malononitrile, aryl aldehydes, and 1,2-ethanedithiol in the presence of a catal

Mixed Metal-Organic Framework as a Heterogeneous Catalyst

The synthesis of a new mixed metal-organic framework (M′MOF) has been accomplished by the metalloligand approach. [NaCu(2,4-HPdc)(2,4-Pdc)] (2,4-H2Pdc = pyridine-2,4-dicarboxylic acid) has been obtained from the hydrothermal reaction of the metalloligand [Cu(2,4-HPdc)2(H2O)2] NaOH, and a transition metal salt. [NaCu(2,4-HPdc)(2,4-Pdc)] is isostructural to [CuMn(2,4-Pdc)2] and crystallizes in the triclinic space group Pβar {1}$. The 3D structure is built up from [Cu(2,4-HPdc)2(H2O)2] metalloligands and [NaO6] octahedra in a pcu α-Po-like uninodal six-connected net. The compound is stable to 290 °C, and its crystal structure undergoes a 3 % volume expansion between room temperature and thermal decomposition. The unsaturated CuII centers at the surface act as a heterogeneous Lewis acid catalyst for the cyanosilylation of aldehydes and Knoevenagel C-C bond-forming reactions. The catalytic activity has been compared with those of other copper(II) porous metal-organic frameworks such as HKUST-1 and MOF-74.

Green approach for Knoevenagel condensation of aromatic aldehydes with active methylene group

An ecofriendly and economical method of Knoevenagel condensation of aromatic aldehydes with malononitrile catalyzed by lemon juice, a natural catalyst, in the absence of any solvent is described. Copyright Taylor & Francis Group, LLC.

Significant Gas Adsorption and Catalytic Performance by a Robust CuII-MOF Derived through Single-Crystal to Single-Crystal Transmetalation of a Thermally Less-Stable ZnII-MOF

By using a bent tetracarboxylic acid ligand that incorporates a pendent -NH2 functional group, a 3D ZnII-framework (1) based on Zn2(CO2)4 secondary building units and Zn12(CO2)s

Multistep Synthesis of Fluorine-Substituted Pyrazolopyrimidine Derivatives With Higher Antibacterial Efficacy Based on In Vitro Molecular Docking and Density Functional Theory

Some new fluorine-substituted pyrazolopyrimidine derivatives (1.3–1.5) have been synthesized by the multistep reactions, starting from reaction of 4-fluorophenyl malanonitrile (1) with guanidine, followed by ring closure reaction with hydrazine to give 2,

Synthesis of two metal-porphyrin frameworks assembled from porphyrin building motifs, 5, 10, 15, 20-tetrapyridylporphyrin and their base catalyzed property

Opening catalytically active sites in metal organic frameworks is an issue of fundamental importance for the development of effective and efficient catalysts. In this work, we first reported two metal metalloporphyrin-organic frameworks (MMPFs) with unocc

Nanochannel-based {BaZn}-organic framework for catalytic activity on the cycloaddition reaction of epoxides with CO2and deacetalization-Knoevenagel condensation

Herein, the rare combination of BaII (5s) and ZnII (3d) in the presence of the structure-oriented TDP6- ligand generated the nanochannel-based hybrid material {[(CH3)2NH2]2[BaZn(TDP)(H2O)]·DMF·5H2O}n (NUC-51, H6TDP = 2,4,6-tri(2,4-dicarboxyphenyl)pyridine), which possesses excellent physicochemical characteristics such as nanoscopic channels, high porosity, large specific surface area, and high heat/water-resistance. To the best of our knowledge, this is the first 3D [BaIIZnII(CO2)6(H2O)]-based nano-porous host framework, whose activated state possesses the coexistence of Lewis acid-base sites including 4-coordinated Zn2+ ions, 7-coordinated Ba2+ ions, uncoordinated carboxyl oxygen atoms, and Npyridine atoms. Catalytic experiments exhibited that activated NUC-51a possesses a high catalytic activity on the cycloaddition reactions of epoxides with CO2 at 55 °C, which can be ascribed to its structural advantages of nanoscale channels and rich bifunctional active sites. Moreover, NUC-51a could significantly accelerate the deacetalization-Knoevenagel condensation reaction in DMSO solvent at 70 °C.