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Usage

Uses

Used in Organic Synthesis:
Piperazine, bis(trifluoroacetate) is used as a reagent in organic synthesis for the production of pharmaceuticals and agrochemicals. Its strong base and nucleophilic properties make it valuable in a variety of chemical reactions.
Used in Catalysts:
Piperazine, bis(trifluoroacetate) is used as a catalyst in certain reactions, enhancing the efficiency and selectivity of the process.
Used in Building Blocks:
Piperazine, bis(trifluoroacetate) serves as a building block for the creation of complex organic compounds, contributing to the development of new molecules with potential applications in various industries.
Safety Precautions:
It is important to handle Piperazine, bis(trifluoroacetate) with care as it can be harmful if inhaled or ingested and may cause skin and eye irritation. Proper safety measures should be taken during its use to minimize potential risks.

Upstream product

• 16419-60-6 2-Methylphenylboronic acid 
• 298-12-4 Glyoxilic acid 
• 76-05-1 trifluoroacetic acid 
• 5720-05-8 4-methylphenylboronic acid 
• 5467-74-3 4-Bromophenylboronic acid 
• 5720-07-0 4-methoxyphenylboronic acid 

Relevant academic research and scientific papers

Universal solid-phase approach for the immobilization, derivatization, and resin-to-resin transfer reactions of boronic acids

Boronic acid-containing molecules are employed in a broad range of biological, medicinal, and synthetic applications. These compounds, however, tend to be difficult to handle by solution-phase methods. Herein, this problem is addressed with the development of the first general solid-phase approach for the derivatization of functionalized boronic acids. This approach is based on the use of a diethanolamine resin anchor that facilitates boronic acid immobilization by avoiding the need for exhaustive removal of water in the esterification process. The immobilization of a wide variety of boronic acids onto N,N-diethanolaminomethyl polystyrene (DEAM-PS, 1) can be performed within minutes by simple stirring in anhydrous solvents at room temperature. Evidence for the formation of a bicyclic diethanolamine boronate with putative N-B coordination was shown by 1H NMR analysis of DEAM-PS-supported p-tolylboronic acid. The hydrolytic cleavage of the same model boronic acid from the DEAM-PS resin was studied by UV spectroscopy. Hydrolysis and attachment were shown to occur under a rapidly attained equilibrium, and a large excess of water (> 32 equiv) is required to effect a practically quantitative release of boronic acids from DEAM-PS. Despite their relative sensitivity to water and alcohols, DEAM-PS-bound arylboronic acids functionalized with a formyl, a bromomethyl, a carboxyl, or an amino group can be transformed in good to excellent yields into a wide variety of amines, amides, anilides, and ureas, respectively. Ugi multicomponent reactions on DEAM-PS-supported aminobenzeneboronic acids, derivatization of multifunctional arylboronic acids, and sequential reactions can also be carried out efficiently. These new DEAM-PS-supported arylboronic acids can be employed directly into resin-to-resin transfer reactions (RRTR). This type of multiresin process helps eliminate time-consuming cleavage and transfer operations, thereby considerably simplifying the outlook of combinatorial library synthesis by manual or automated means. This concept was illustrated by a set of optimized procedures for the Suzuki cross-coupling and the borono-Mannich reactions.