77200-24-9

Usage

Uses

Used in Organic Synthesis:
1-(2-Chloroethyl)pyrrole is used as a building block for the synthesis of more complex organic molecules, leveraging its unique structure and reactivity to form a variety of compounds with diverse applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(2-chloroethyl)pyrrole is used as a key intermediate in the development of pharmaceutical compounds. Its chemical properties allow for the creation of new drugs with potential therapeutic effects.
Used in Pharmaceutical Industry:
1-(2-Chloroethyl)pyrrole is utilized as a reagent in the pharmaceutical industry for the introduction of chloroethyl functionality into other organic compounds, which can enhance the pharmacological properties of these compounds.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, 1-(2-chloroethyl)pyrrole serves as a reagent to introduce chloroethyl groups into agrochemical compounds, potentially improving their effectiveness and selectivity.

InChI:InChI=1/C6H8ClN/c7-3-6-8-4-1-2-5-8/h1-2,4-5H,3,6H2

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 870-24-6 2-chloroethanamine hydrochloride 
• 109-97-7 pyrrole 
• 107-06-2 1,2-dichloro-ethane 
• 80-41-1 2-chloroethyl tosylate 
• 16199-06-7 potassium pyrrolide 

Downstream Products

• 131727-07-6 N-(phenyl)-N-[1-(2-(1H-pyrrol-1-yl)ethyl)-4-methoxymethyl-4-piperidinyl]propanamide 
• 131727-05-4 N-(phenyl)-N-[1-(2-(1H-pyrrol-1-yl)ethyl)-4-methoxycarbonyl-4-piperidinyl]propanamide 
• 1443120-54-4 2-(4-propoxyphenyl)-4-[2-(1H-pyrrol-1-yl)ethoxy]quinoline 
• 100911-22-6 N-methyl-2-pyrrol-1-yl-ethanamine 
• 1392291-33-6 (4-isopropoxy-3-methoxyphenyl)(2'-methyl-6'-(trifluoromethyl)-3',4'-dihydro-2'H-spiro[piperidine-4,1'-pyrrolo[1,2-a]pyrazine]-1-yl)methanone 

Relevant academic research and scientific papers

A stimulus-responsive poly-pyrrole nano tube targeted drug carrier and its preparation method

The invention provides a stimulus-response type polypyrrole nanotube targeting drug carrier and a preparation method. A titanium dioxide nanotube array or a porous anodic alumina array serves as a template, and a polypyrrole nanotube is prepared through chemical vapor deposition; beta-cyclodextrin and a tube opening of a polypyrrole nanotube are connected through stimulus response type sensitive bonds such as acyl hydrazone bonds and disulfide bonds, and medicine can be blocked in the nanotube and released out in the faintly acid and reducibility environments; one end of a polyethylene glycol chain is connected with a folic acid targeted molecule, the other end of the polyethylene glycol chain is connected with an adamantane head base, the adamantane head base is linked up to a beta-cyclodextrin hydrophobic cavity through host and guest envelope, and folic acid molecules recognize tumor cells through a receptor-ligand medium. The stimulus-response type polypyrrole nanotube targeting drug carrier prepared through the method is uniform in particle diameter size distribution, controllable in appearance, stable in product, simple in synthesis process, low in cost and suitable for mass production.

SOLID FORMS OF (4-ISOPROPOXY-3-METHOXYPHENYL)(2'-METHYL-6'-(TRIFLUOROMETHYL)-3',4'-DIHYDRO-2'H-SPIRO[PIPERIDINE-4,1'-PYRROLO[1,2-A]PYRAZINE]-1-YL)METHANONE

The invention relates to solid state forms, for example, crystalline forms, of (4-isopropoxy-3-methoxyphenyl)(2'-methyl-6'-(trifluoromethyl)-3,,4'- dihydro-2'H-spiro[piperidine-4, 1 '-pyrrolo[ 1,2-a]pyrazine]- 1 -yl)methanone (Compound 1) or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods therewith. The present invention also relates to a method of preparing Compound 1 in various solid forms. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders such as pain.

PYRROLOPYRAZINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS

The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Synthesis of vinyl monomers with active azaaromatic groups. Phase-transfer catalytic approach

An efficient method based on the alkylation-elimination reactions under solid-liquid phase transfer-catalysis conditions (S/L PTC) is reported for the preparation of N-vinyl derivatives of azaheterocyclic compounds.