1-(2-CHLOROETHYL)PYRROLE

Base Information

• Chemical Name: 1-(2-CHLOROETHYL)PYRROLE
• CAS No.: 77200-24-9
• Molecular Formula: C6H8ClN
• Molecular Weight: 129.59
• Hs Code.: 2933998090
• Mol file: 77200-24-9.mol

Synonyms:1-(2-Chloroethyl)-1H-pyrrole;

Chemical Property of 1-(2-CHLOROETHYL)PYRROLE

Chemical Property:

• Vapor Pressure: 0.985mmHg at 25°C
• Refractive Index: 1.514
• Boiling Point: 184.818 °C at 760 mmHg
• PKA: -3.55±0.70(Predicted)
• Flash Point: 65.576 °C
• PSA: 4.93000
• Density: 1.077 g/cm³
• LogP: 1.72690
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-Chloroethyl)pyrrole ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-CHLOROETHYL)PYRROLE

There total 3 articles about 1-(2-CHLOROETHYL)PYRROLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + 2-chloroethanamine hydrochloride (870-24-6) → 1-(2-chloroethyl)-1H-pyrrole (77200-24-9)

Guidance literature:

With sodium acetate; acetic acid; at 110 ℃; for 2h;

Reference yield: 39.0%

pyrrole (109-97-7,30604-81-0) + 1,2-dichloro-ethane (107-06-2,52399-93-6) → 1-(2-chloroethyl)-1H-pyrrole (77200-24-9)

Guidance literature:

With potassium hydroxide; tetrabutylammomium bromide; potassium carbonate; at 45 - 50 ℃; for 4.5h;

DOI:10.1080/00397910008086974

Reference yield:

2-chloroethyl tosylate (80-41-1) + potassium pyrrolide (16199-06-7) → 1-(2-chloroethyl)-1H-pyrrole (77200-24-9)

Guidance literature:

With benzene;

DOI:10.1039/jr9310000049

upstream raw materials:

2-chloroethyl tosylate

potassium pyrrolide

cis,trans-2,5-dimethoxytetrahydrofuran

2-chloroethanamine hydrochloride

Downstream raw materials:

2-(4-propoxyphenyl)-4-[2-(1H-pyrrol-1-yl)ethoxy]quinoline

N-methyl-2-pyrrol-1-yl-ethanamine

(4-isopropoxy-3-methoxyphenyl)(2'-methyl-6'-(trifluoromethyl)-3',4'-dihydro-2'H-spiro[piperidine-4,1'-pyrrolo[1,2-a]pyrazine]-1-yl)methanone

N-(phenyl)-N-[1-(2-(1H-pyrrol-1-yl)ethyl)-4-methoxycarbonyl-4-piperidinyl]propanamide

Refernces

• 1、 -. "SOLID FORMS OF (4-ISOPROPOXY-3-METHOXYPHENYL)(2'-METHYL-6'-(TRIFLUOROMETHYL)-3',4'-DIHYDRO-2'H-SPIRO[PIPERIDINE-4,1'-PYRROLO[1,2-A]PYRAZINE]-1-YL)METHANONE". Paragraph 00177-00178. . Retrieved 2014/02/16.
• 2、 Bogdal, Dariusz,Jaskot, Krzysztof. "Synthesis of vinyl monomers with active azaaromatic groups. Phase-transfer catalytic approach". . p. 3341 - 3352. Retrieved 2007/10/03.