77203-11-3

Basic information

• Product Name: 5 - chloro-acetamido-N, N - bis (2,3 - dihydroxypropyl) -2,4,6 - triiodo-1 ,3. Phthalimido
• Synonyms: 5 - chloro-acetamido-N, N - bis (2,3 - dihydroxypropyl) -2,4,6 - triiodo-1 ,3. Phthalimido;N,N'-bis(2,3-dihydroxypropyl)-5-(chloroacetamido)-2,4,6-triiodo-1,3-Benzenedicarboxamide
• CAS NO: 77203-11-3
• Molecular Formula: C₁₆H₁₉ClI₃N₃O₇
• Molecular Weight: 781.5
• Product Categories: Intermediate of Ioversol
• Mol File: 77203-11-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 765.7±60.0 °C(Predicted)
• Appearance: /
• Density: 2.314±0.06 g/cm3(Predicted)
• PKA: 9.83±0.70(Predicted)
• CAS DataBase Reference: 5 - chloro-acetamido-N, N - bis (2,3 - dihydroxypropyl) -2,4,6 - triiodo-1 ,3. Phthalimido(CAS DataBase Reference)
• NIST Chemistry Reference: 5 - chloro-acetamido-N, N - bis (2,3 - dihydroxypropyl) -2,4,6 - triiodo-1 ,3. Phthalimido(77203-11-3)
• EPA Substance Registry System: 5 - chloro-acetamido-N, N - bis (2,3 - dihydroxypropyl) -2,4,6 - triiodo-1 ,3. Phthalimido(77203-11-3)

Safety Data

• Hazardous Substances Data: 77203-11-3(Hazardous Substances Data)

Upstream product

• 37441-29-5 5-amino-2,4,6-triiodoisophthalic acid dichloride 
• 35453-19-1 2,4,6-triiodo-5-aminoisophthalic acid 
• 76801-93-9 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide 
• 79-04-9 chloroacetyl chloride 
• 155887-14-2 N,N'-bis[2,3-di(2-chloroacetoxy)propyl]-5-(2-chloroacetamido)-2,4,6-triiodoisophthalamide 

Downstream Products

• 849668-82-2 N,N'-bis(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl) (2-chloroacetamido)]-2,4,6-triiodoisopthalamide 
• 87771-40-2 ioversol 
• 104517-96-6 N,N'-bis(2,3-dihydroxypropyl)-5-[[N-(2-hydroxyethyl)-carbamoyl]methoxy]-2,4,6-triiodoisophthalamide 

Relevant articles and documents

9 - Azabicyclo [3.3.1] nonane coupling [...] compound and its preparation method and use thereof (by machine translation)

The invention discloses a 9 - azabicyclo [3.3.1] nonane coupling [...] compound, its preparation method comprises the following steps: in the organic solvent, the 9 - nitrogen (6' - amino) oneself amidogen - 9 - 9 - azabicyclo [3.3.1] nonane - 3 α - alkyl amino formic acid benzene and chloro acetyl three iodo aniline derivatives in accordance with the 1: 1.0 - 1.5 molar ratio, for the catalysis of cesium hydroxide at room temperature reaction in the 20 - 30 the H, obtained as the product of the 9 - azabicyclo [3.3.1] nonane coupling [...] compound. The invention also discloses the use thereof: a contrast agent for early diagnosis of breast cancer. (by machine translation)

Ioversol preparation method

The present invention provides an ioversol preparation method, particularly a continuous ioversol preparation method, wherein the product is subjected to desalting and purifying to prepare the high-purity ioversol. According to the present invention, the production process is simplified, the generation of the difficultly-removed impurities is effectively controlled, and the method is suitable for industrial production.

PROCESSES FOR THE PREPARATION OF PURE IOVERSOL

The invention relates to processes for the preparation of pure ioversol. The invention also relates to processes for the preparation of N,N'-bis(2,3-dihydroxypropyl)-5-(2- chloroacetamido)-2,4,6-triiodoisophthalamide and N,N'-bis(2,3-dihydroxypropyl)-5- [N-(2-hydroxyethyl)-2-chloroacetamido] -2,4,6-triiodoiso phthalamide, useful intermediates for the preparation of ioversol.