77203-11-3Relevant academic research and scientific papers
9 - Azabicyclo [3.3.1] nonane coupling [...] compound and its preparation method and use thereof (by machine translation)
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, (2018/11/22)
The invention discloses a 9 - azabicyclo [3.3.1] nonane coupling [...] compound, its preparation method comprises the following steps: in the organic solvent, the 9 - nitrogen (6' - amino) oneself amidogen - 9 - 9 - azabicyclo [3.3.1] nonane - 3 α - alkyl amino formic acid benzene and chloro acetyl three iodo aniline derivatives in accordance with the 1: 1.0 - 1.5 molar ratio, for the catalysis of cesium hydroxide at room temperature reaction in the 20 - 30 the H, obtained as the product of the 9 - azabicyclo [3.3.1] nonane coupling [...] compound. The invention also discloses the use thereof: a contrast agent for early diagnosis of breast cancer. (by machine translation)
Preparation method of ioversol
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Paragraph 0063; 0064, (2017/05/10)
The invention provides a preparation method of ioversol. Particularly, the method provided by the invention comprises the following steps: carrying out alkylation reaction on 5-chloracetylamino-N,N'-bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-phenyldiformamide and chloroethanol by using sodium hydroxide/sodium borate or sodium hydroxide/lithium chloride; and meanwhile, directly hydrolyzing the product by a one-pot multistep process, and carrying out desalting and purification to prepare the ioversol. The method simplifies the production technique process, effectively controls the generation of irremovable impurities, and is suitable for industrial production.
Ioversol preparation method
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Paragraph 0050; 0051, (2017/10/24)
The present invention provides an ioversol preparation method, particularly a continuous ioversol preparation method, wherein the product is subjected to desalting and purifying to prepare the high-purity ioversol. According to the present invention, the production process is simplified, the generation of the difficultly-removed impurities is effectively controlled, and the method is suitable for industrial production.
Preparation method for ioversol
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Paragraph 0060; 0061, (2017/07/19)
The invention provides a preparation method for ioversol. Specifically speaking, the method comprises the following steps: (1) performing an alkylation reaction on 5-chloracetyl amino-N,N'-bi-(2,3- dyhydroxyl propyl)-2,4,6-triiodo-1,3-phthalic diamide and chlorethyl alcohol under an alkaline condition; (2) hydrolyzing through sodium acetate to obtain the ioversol. A container of which the inner wall is coated with a corrosion-resistant coating is used in the reactions of the former two steps, and the water with the iron content of below 0.05 ppm is used. The method can effectively avoid the production of impurities which are difficult to remove, and is suitable for industrial production.
PROCESSES FOR THE PREPARATION OF PURE IOVERSOL
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Page/Page column 5; 11, (2008/12/07)
The invention relates to processes for the preparation of pure ioversol. The invention also relates to processes for the preparation of N,N'-bis(2,3-dihydroxypropyl)-5-(2- chloroacetamido)-2,4,6-triiodoisophthalamide and N,N'-bis(2,3-dihydroxypropyl)-5- [N-(2-hydroxyethyl)-2-chloroacetamido] -2,4,6-triiodoiso phthalamide, useful intermediates for the preparation of ioversol.
Process for producing ioversol
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, (2008/06/13)
The present invention discloses a new process for producing ioversol (marketed as OPTIRAY) comprising:(a) reacting 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisopthalamide with chloroacetyl chloride in a polar aprotic solvent or combinations there
Process for producing ioversol
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, (2008/06/13)
The present invention discloses a new process for producing ioversol (marketed as OPTIRAY) comprising: (a) reacting 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisopthalamide with chloroacetyl chloride in a polar aprotic solvent, or combinations the
