77203-44-2

Usage

Uses

Since the provided materials do not explicitly mention the uses of (6Z)-6-([4-(4-chlorophenyl)-1,3-thiazol-2-yl]aminomethylidene)cyclohexa-2,4-dien-1-one, we can only infer potential applications based on its structural features and the general uses of similar compounds. Here are some possible applications:
Used in Pharmaceutical Industry:
(6Z)-6-([4-(4-chlorophenyl)-1,3-thiazol-2-yl]aminomethylidene)cyclohexa-2,4-dien-1-one could be used as a building block or a precursor for the synthesis of novel pharmaceuticals, given its thiazole and cyclohexenone functional groups. These groups are often associated with bioactive compounds, which may have potential applications in the development of new drugs.
Used in Chemical Research:
(6Z)-6-([4-(4-chlorophenyl)-1,3-thiazol-2-yl]aminomethylidene)cyclohexa-2,4-dien-1-one may also be utilized in academic and industrial chemical research as a model or reference compound for studying the properties and reactivity of thiazole and cyclohexenone-containing molecules. Understanding its behavior could lead to the discovery of new synthetic methods or applications in various chemical processes.
Used in Material Science:
(6Z)-6-([4-(4-chlorophenyl)-1,3-thiazol-2-yl]aminomethylidene)cyclohexa-2,4-dien-1-one's unique structure may offer potential applications in the field of material science, where it could be investigated for its properties, such as conductivity, stability, or reactivity, which could be harnessed in the development of new materials with specific characteristics.

Upstream product

• 2103-99-3 4-(4-chlorophenyl)-2-thiazolamine 
• 90-02-8 salicylaldehyde 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 77203-88-4 2-[[4-(4-Chloro-phenyl)-thiazol-2-ylamino]-(2-hydroxy-phenyl)-methyl]-cyclohexanone 
• 77204-01-4 4-(4-Chloro-phenyl)-2'-(2-hydroxy-phenyl)-[2,3']bithiazolyl-4'-one 

Relevant academic research and scientific papers

Biological evaluation and synthesis of thiazole schiff base derivatives

In this study, we report the synthesis of thiazole Schiff base derivatives (Z1-Z16) and their tyrosinase inhibitory activity, anti-oxidant activities. Mushroom tyrosinase inhibitory assay showed compound Z8 (IC50 = 2.78 ± 0.08 μM) inhibited tyrosinase more than kojic acid (49.39 ± 0.17 μM), and docking study indicated compound Z8 (-7.32 kcal/mol) had stronger binding affinities for tyrosinase than kojic acid (-5.7 kcal/mol). Phenolic hydroxyl group on 4-position (R2) of compound Z8 can form Metal - Acceptor with Cu401. The results of inhibition kinetics studies demonstrated that compound Z8 was mixed type inhibitor. The anti-browning effects manifested compound Z8 expressed satisfactory effects in anti-browning of fresh-cut apples and fresh-cut potato. All the results indicated that thiazole Schiff base derivatives might be promising leading compounds as tyrosinase inhibitors and anti-oxidant agents.

2-Hydroxybenzylidene-4-(4-SubstitutedPhenyl)-2-amino Thiazole and their Pt (II) complexes: Synthesis, characterization and biological study

Newly prepared Schiff bases; 2-Hydroxybenzylidene-4-x-phenyl)-2-aminothiazole,where x=H NO2 - CH3, -OCH3, –F, and -Cl (L1-L6), and their corresponding Pt (II) complexes (Pt(L1)s

L-Proline as an efficient catalyst for synthesis of aldimines at ambient temperature condition

Some new aldimines were synthesized from substituted 2-amino thiazoles and different aromatic aldehydes using L-proline as an efficient catalyst. The structure elucidation of aldimines has been made on the basis of elemental analysis and spectral data. Th

Synthesis and Biological Activity of Some Schiff Bases Derived from Thiazoles and Benzothiazoles

4-Aryl-2-aminothiazoles and 2-aminobenzothiazoles undergo condensation with salicylaldehyde in the presence of piperidine to give the schiff bases II and III, respectively.A similar reaction of 4-aryl-2-aminothiazole methiodides gives the schiff bases 4-aryl-2-(2'-hydroxyaryliminomethyl)thiazole methiodides (IV).Several schiff bases have been condensed with cyclohexanone and thioglycollic acid to furnish 4-aryl-2-(2'-hydroxy-α-substituted benzylamino)thiazoles (V) and 2-(2'-hydroxyphenyl) or naphthyl)-3-(4''-arylthiazol-2''-yl)-4-thiazolidones (VI), respectively.Structure elucidation of the schiff bases has been made on the basis of their elemental analyses, IR and mass spectral data.The biological screening data of the schiff bases and their metal complexes are also presented.

Kinetics of Hydrolysis of N-Salicylidene-2-amino-4-substituted-phenylthiazoles

The kinetics of hydrolysis of schiff bases, N-salicylidene-2-amino-(4-substituted phenyl)thiazoles have been investigated in 20percent ethanol-water at 30.0 +/- 0.5 deg C, pH = 4.05-5.90 and I = 0.05 mol dm-3.The reaction proceeds via uncatalys