7721-66-6Relevant academic research and scientific papers
Enols of carboxylic acid amides with β-electron-withdrawing substituents
Mukhopadhyaya, Jayanta Kumar,Sklenak, Stepan,Rappoport, Zvi
, p. 1325 - 1336 (2000)
The effect of stabilizing enols of carboxamides by several two β- electron-withdrawing substituents was studied with the R1R2CHCONHPh systems. When R1R2CH2 = Meldrum's acid (MA), the solid-state structure is that of the enol R1R2C=C(OH)NHPh (7). In CDCl3 solution the structure is 7, but there may be some exchange on the NMR time scale with a tautomer. B3LYP/6-31G** calculations show a significant preference for the enol R1R2C=C(OH)NH2 (12a) (R1R2C = MA moiety) and a small preference for (MeO2C)2C=C(OH)NHPh (11b) over the amide structures. However, solid 11 has the amide structure (MeO2C)2CHCONHPh (11a). NMR spectra in CDCl3 show >90% of 11a, but a minor species, probably 11b, is also present. In DMSO this species is not observed. The analogous dimedone-substituted anilide 10 exists both in the solid state and in solution as an enol of a ring carbonyl. Calculations show that HC(CO2Me)3 has a lower energy than its tautomeric enol. The effects of the push-pull structures of the enols on structural and spectrometric parameters, of the β-substituents, of the planarity of the system, of the acid derivative group (ester or anilide), and of the solvent as enol-stabilizing factors are discussed. Destabilization of the acid form contributes to the increased relative stability of the enols.
Technique for producing insecticide from carbon dioxide
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, (2019/03/31)
A technique for producing an insecticide from carbon dioxide comprises the following steps: weighing a 1,3-cyclohexanedione substrate, a catalyst and Cs2CO3 in a Schleck bottle, degassing, and continuously introducing 1 atm carbon dioxide; adding a solven
Synthesis, Structure–Activity Relationship Studies, and ADMET Properties of 3-Aminocyclohex-2-en-1-ones as Chemokine Receptor 2 (CXCR2) Antagonists
Dai, Weiyang,Chen, Wenmin,Debnath, Bikash,Wu, Yong,Neamati, Nouri
, p. 916 - 930 (2018/05/15)
Herein we describe the synthesis and structure–activity relationships of 3-aminocyclohex-2-en-1-one derivatives as novel chemokine receptor 2 (CXCR2) antagonists. Thirteen out of 44 derivatives were found to inhibit CXCR2 downstream signaling in a Tango a
Triphenylbismuthonio-4,4-dimethyl-2,6-dioxocyclohexane-1-ide and Triphenylbismuthonio-4,4-dimethyl-2,6-dioxo-3,5-dioxan-1-ide. Preparation and Properties of the Stable Bismuthonium Ylides
Suzuki, Hitomi,Murafuji, Toshihiro,Ogawa, Takuji
, p. 847 - 848 (2007/10/02)
The title two bismuthonium ylides were obtained in pure form and their reactions with some electrophiles were studied.In contrast with stable ylides of arsenic and antimony, these bismuthonium ylides readily react sith aldehydes and isothiocyanates but th
