77210-18-5

Upstream product

• 77945-44-9 (2S,6R,7R)-7-Benzoylamino-3-chloro-3-hydroxymethyl-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester 
• 67977-91-7 (2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester 
• 865-34-9 lithium methanolate 
• 77982-91-3 (6R,7R)-3-Acetoxymethyl-7-benzoylamino-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Downstream Products

• 116180-23-5 (6R,7R)-3-Acetoxymethyl-7-amino-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 77930-80-4 (6R,7R)-3-Acetoxymethyl-7-[5-tert-butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 77930-85-9 (6R,7R)-3-Acetoxymethyl-7-(5-tert-butoxycarbonylamino-5-carboxy-pentanoylamino)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

CONVENIENT SYNTHESIS OF 3'-SUBSTITUTED METHYL 7α-METHOXY-1-OXACEPHEMS

A convenient synthesis of the title compounds 1 is achieved by formation of glycols 3, 12, 13 and 14 or chlorohydrins 6 from epioxazolines having pertinent allylic substituents, followed by stereoselective, intramolecular etherification to 4, 7, 15, 16 an

SYNTHESIS OF 1-OXA ANALOGUES OF NATURALLY OCCURRING CEPHALOSPORINS AND CEPHAMYCINS

The title compounds 15a-c and 16a-c were synthesized from a 3-exomethylene-1-oxacepham compound 4.Its chlorohydroxylation provided a key intermediate 5e in synthesis of the 3'-oxygen-functionalized 1-oxacephems.