77210-51-6

Usage

Uses

Used in Pharmaceutical Industry:
(S)-(FLUOROMETHYL)-BENZENEETHANAMINE HYDROCHLORIDE is used as a building block for the preparation of novel biologically active molecules, due to its unique structural features. It plays a crucial role in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
(S)-(FLUOROMETHYL)-BENZENEETHANAMINE HYDROCHLORIDE is used as a component in the synthesis of various agrochemicals, contributing to the development of new products for agricultural applications.
Used in Fine Chemicals Production:
(S)-(FLUOROMETHYL)-BENZENEETHANAMINE HYDROCHLORIDE has potential utility as an intermediate in the production of fine chemicals, dyes, and other specialty organic compounds, thanks to its versatile chemical properties and reactivity.

Upstream product

• 13906-90-6 2-benzylaziridine 
• 717128-19-3 (S)-2-(N,N-diallylamino)-3-phenylpropan-1-ol 
• 3182-95-4 L-Phenylalaninol 

Downstream Products

• 1146971-53-0 (S)-N-(1-fluoro-3-phenylpropan-2-yl)-N-methylprop-2-yn-1-amine 

Relevant academic research and scientific papers

Nucleophilic Fluorination and Radiofluorination via Aziridinium Intermediates: N-Substituent Influence, Unexpected Regioselectivity, and Differences between Fluorine-19 and Fluorine-18

The efficient dehydrofluorination and radiofluorination of N,N-disubstituted-β-aminoalcohols through an anchimeric-assisted mechanism was developed. An investigation into the influence of N-substituents on the ring opening of the aziridinium intermediate indicated differences in the isomeric ratio and the yields of fluorinated products obtained from N,N-disubstituted-phenylalaninol. This influence was substantial for 18F-radiofluorination, with yields varying from 0 to 71% at room temperature (RT). Although no significant effects were observed in the fluorine-19 chemistry when the reaction was heated to 90 °C, considerable changes appeared during radiofluorination. In the latter case, the radiochemical yields increased, and degradation of the 2-fluoro-propan-1-amine isomer (b) occurred, leading to a regiospecific reaction in the radiolabeling of [18F]-fluorodeprenyl. This method involving nucleophilic radiofluorination at RT was successfully applied to the radiolabeling of [18F]-2-fluoroethylamines in which the influence of the N-substituent was also observed.

SYNTHESIS OF SIDE-CHAIN MONOFLUORINATED AMPHETAMINES

R- and S-2-Amino-3-fluoro-1-phenylpropane were prepared in approximately 50percent yields by the action of HF-pyridine on R- and S-2-bezylaziridene, (+/-)-2-Amino-3-fluoro-1-(4-chlorophenyl)propane was similarly prepared from (+/-)-2-(4-chlorobenzyl)aziri