77211-74-6Relevant academic research and scientific papers
N-(HETERO)ARYL-SUBSTITUTED HETEROYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES OR CONDITIONS RELATED TO THE CENTRAL NERVOUS SYSTEM
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, (2016/04/20)
The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease, disorder or condition ameliorated by inhibition of a dopamine transporter); and methods of treating patients with such compounds; wherein R1, R2, R3, R4, R9a, R9b, R9c, R9d, R9e, R9f, m, n, A, L and B are as defined herein.
1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents
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, (2008/06/13)
Compounds of the formula STR1 wherein R1, R2 and R3 are the same or different and are hydrogen, C1 to C6 alkyl, C6 to C14 carbocyclic aryl or aralkyl of 1 to 6 carbon atoms in the alkyl moiety and 6 to 12 carbon atoms in the carbocyclic aryl moiety and R4 is selected from the group having the formula STR2 where R is C1 to C8 alkyl, C1 to C8 alkoxy, halo, cyano, AlkNHC(O)-- or AlkC(O)NH-- and R' is Alk NHC(O) or Alk C(O)NH where Alk is C1 to C6 alkyl or the group 2-(endobicyclo[3.1.0]hexyl)ethyl. Methods for preparing the compounds are disclosed. The compounds are useful for the treatment of hypertension and cardiac disorders.
8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof
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, (2008/06/13)
Compounds of the formula STR1 wherein R1, R2 and R3 are the same or different and are hydrogen, C1 to C6 alkyl, C6 to C12 carbocyclic aryl or aralkyl of 1 to 6 carbon atoms in the alkyl moiety and 6 to 12 carbon atoms in the carbocyclic aryl moiety; R4 and R5 are the same or different and are hydrogen or C1 to C6 alkyl; and R6 and R7 are the same or different and are hydrogen, C1 to C6 alkyl or C1 to C6 alkoxy. Methods for preparing these compounds are also disclosed. The compounds are useful as antihypertensives and as diuretics. They also function as antihistamines and as bronchodilating agents and are therefore effective in inhibiting the effects of allergic reactions. They are also of use in the treatment of migraine and in the treatment of vasospastic disorders.
