77223-21-3

Usage

Uses

Used in Pharmaceutical Industry:
7-CHLORO-2,4-DIMETHYL-[1,8]NAPHTHYRIDINE is used as a building block for the synthesis of drug compounds due to its potent antimicrobial and anti-inflammatory properties. It plays a crucial role in the development of new medications for the treatment of infections and inflammatory conditions.
Used in Agricultural Products:
7-CHLORO-2,4-DIMETHYL-[1,8]NAPHTHYRIDINE may be utilized as a pesticide or antibacterial agent in agricultural products. Its antimicrobial properties make it a potential candidate for protecting crops from bacterial infections and enhancing overall crop health.
Used in Veterinary Products:
In the veterinary industry, 7-CHLORO-2,4-DIMETHYL-[1,8]NAPHTHYRIDINE could be employed as a pesticide or antibacterial agent to prevent and treat infections in animals, contributing to the overall health and well-being of livestock.
The unique structure and functional properties of 7-CHLORO-2,4-DIMETHYL-[1,8]NAPHTHYRIDINE make it a valuable and versatile chemical across various fields, including medicine and agriculture.

InChI:InChI=1/C10H9ClN2/c1-6-5-7(2)12-10-8(6)3-4-9(11)13-10/h3-5H,1-2H3

Upstream product

• 51420-71-4 5,7-dimethyl-1,8-naphthyridin-2(1H)-one 
• 141-86-6 2.6-diaminopyridine 
• 123-54-6 acetylacetone 
• 51420-71-4 2-hydroxyl-5,7-dimethyl-1,8-naphthyridine 
• 27224-55-1 C₉H₁₀N₄ 
• 17884-12-7 C₉H₉N₃O 
• 39565-07-6 7-amino-2,4-dimethyl-1,8-naphthyridine 

Downstream Products

• 91860-11-6 2-[(5,7-Dimethyl-[1,8]naphthyridin-2-yl)-(2-hydroxy-ethyl)-amino]-ethanol 
• 144101-82-6 7-diphenylphosphino-2,4-dimethyl-1,8-naphthyridine 
• 1025726-26-4 2,4-dimethyl-7-p-tolyl-1,8-naphthyridine 
• 958231-61-3 2-[N-(2-pyridyl)methyl]amino-5,7-dimethyl-1,8-naphthyridine 
• 958231-59-9 2-[N-(2,4-dimethyl-1,8-naphthyridyl)]amino-5,7-dimethyl-1,8-naphthyridin-7-yl 
• 65541-95-9 5,7-dimethyl-1,2,3,4-tetrahydro[1,8]naphthyridine 
• 7544-64-1 2,4-dimethyl[1,8]naphthyridine 

Relevant academic research and scientific papers

1,8-naphthyridine modified naphthalimide derivative: Ratiometric and selective sensor for hg2+ in organic aqueous solution

A bottom-modified (4-position) naphthalimide derivative 1 with 1,8-naphthyridine as binding site has been designed and synthesized. Compound 1 is the first 1,8-naphthyridine-modified naphthalimide-based sensor that can detect Hghg2+ selectively with respect to ratiometric fluorescent change and blue shift in organic aqueous solution. The Job's plot and FAB mass indicate that 1 formed a 1:1 complex with Hg2+. A top-modified naphthalimide derivative 2 with 1,8-naphthyridin as binding site has also been synthesized for comparison.

Cu(I) and Pb(II) complexes containing new tris(7-naphthyridyl)methane derivatives: Synthesis, structures, spectroscopy and geometric conversion

Two novel facial-capping tris-naphthyridyl compounds, 2-chloro-5-methyl-7- ((2,4-dimethyl-1,8-naphthyridin-7(1H)-ylidene)(2,4-dimethyl-1, 8-naphthyridin-7-yl))methyl-1,8-naphthyridine (L1) and 2-chloro-7-((2-methyl-1,8-naphthyridin-7(1H)-ylidene)(2-methyl-1, 8-naphthyridin-7-yl))methyl-1,8-naphthyridine (L2), as well as their Cu(I) and Pb(II) complexes, [CuLa(PPh3)]BF4 (1) (PPh3 = triphenylphosphine, La = bis(2,4-dimethyl-1,8- naphthyridin-7-yl)(2-chloro-5-methyl-1,8-naphthyridin-7-yl)methane), [CuL b(PPh3)]BF4 (2) (Lb = bis(2-methyl-1,8-naphthyridin-7-yl)(2-chloro-1,8-naphthyridin-7-yl)methane), [Pb(OLa)(NO3)2] (3) (OLa = bis(2,4-dimethyl-1,8-naphthyridin-7-yl)(2-chloro-5-methyl-1,8-naphthyridin-7-yl) methanol) and [Pb(Lb)2][Pb(CH3OH)(NO 3)4] (4), have been synthesized and characterized by X-ray diffraction analysis, MS, NMR and elemental analysis. The structural investigations revealed that the transfer of the H-atom at the central carbon to an adjacent naphthyridine-N atom affords L1 and L2 possessing large conjugated architectures, and the central carbon atoms adopt the sp2 hybridized bonding mode. The reversible hydrogen transfer and a geometric configuration conversion from sp2 to sp3 of the central carbon atom were observed when Pb(II) and Cu(I) were coordinated to L1 or L2. The molecular energy changes accompanying the hydrogen migration and titration of H+ to different receptor-N at L1 were calculated by density functional theory (DFT) at the SCRF-B3LYP/6-311++G(d,p) level in a CH2Cl2 solution, and the observed lowest-energy absorption and emission for L1 and L 2 can be tentatively assigned to an intramolecular charge transfer (ICT) transition in nature.

Substituted 1,8-naphthyridines, their preparation and their use as antidotes

A combination of a variety of herbicides with safening agents which are substituted 1,8-naphthyridines of the formula STR1 where R1 is mercapto, hydroxyl, halogen, benzylthio, amino or NR2 R3, where R2 is a grou

Pyridine and related aza heterocycle derivatives as cardiovascular agents

Novel pharmaceutical compounds and compositions having nitrogen containing ring systems which may be represented by the following structural formula: wherein R1 or R3 is a moiety of the formula: wherein R6 is selected from either hydrogen or acetyl; R7 is selected from 2, 3 or 4-pyridyl or 1-imidazolyl and Q is -(CH2)n, where n is an integer from 1 to 5 and R1 and R2, R2 and R3, R3 and R4 or R4 and R5 taken together may be -CH=CH-CH=CH-. The compounds and compositions are useful as inhibitors of thromboxane synthetase and in the treatment of hypertension and arrythmia in mammals.