77232-15-6

Upstream product

• 122-00-9 para-methylacetophenone 
• 27835-00-3 ethyl (4-methylbenzoyl)acetate 
• 1670-14-0 benzamidine monohydrochloride 
• 2227-58-9 3-(4-methylphenyl)prop-2-ynoic acid 
• 14062-19-2 p-tolylacetic acid ethyl ester 

Downstream Products

• 1447910-70-4 dimethyl 6-oxo-2-phenyl-4-p-tolyl-1,6-dihydropyrimidin-5-ylphosphonate 
• 1579270-48-6 2-phenyl-6-(p-tolyl)-5-(trifluoromethyl)pyrimidin-4(3H)-one 
• 77232-05-4 4-(4-methylphenyl)-2-phenylpyrimidine 
• 77232-43-0 4-(2-Phenyl-pyrimidin-4-yl)-benzaldehyde 
• 77232-42-9 4-(4-Bromomethyl-phenyl)-2-phenyl-pyrimidine 
• 77232-33-8 4-Methoxy-2-phenyl-6-p-tolyl-pyrimidine 
• 77232-46-3 4-(6-Methoxy-2-phenyl-pyrimidin-4-yl)-benzaldehyde 
• 77232-45-2 4-(4-Bromomethyl-phenyl)-6-methoxy-2-phenyl-pyrimidine 
• 77232-44-1 (4-Chloro-phenyl)-[1-[4-(2-phenyl-pyrimidin-4-yl)-phenyl]-meth-(E)-ylidene]-amine 
• 77232-47-4 (4-Chloro-phenyl)-[1-[4-(6-methoxy-2-phenyl-pyrimidin-4-yl)-phenyl]-meth-(E)-ylidene]-amine 

Relevant academic research and scientific papers

Manganese(III)-mediated direct Csp2-H radical trifluoromethylation of coumarins with sodium trifluoromethanesulfinate

Mn(OAc)3-mediated direct Csp2-H radical trifluoromethylation of coumarins with CF3SO2Na (Langlois reagent) to afford selective 3-trifluoromethyl coumarins in moderate to good yields is described. This methodology can also be applied to the trifluoromethylation of quinolinones and pyrimidinones. The Royal Society of Chemistry 2014.

A metal-free tandem approach to prepare structurally diverse N-heterocycles: Synthesis of 1,2,4-oxadiazoles and pyrimidinones

A metal-free one-pot approach to the diversity oriented synthesis of N-heterocycles, 1,2,4-oxadiazoles and 2,6 disubstituted pyrimidin-4-ones is described via carboxamidation of amidines with aryl carboxylic acids and aryl propargylic acids. The reactions occur at room temperature forming N-acylamidines which undergo tandem nucleophilic addition-deamination- intramolecular cyclisation to give the corresponding heterocyclic compounds in good to excellent yields. This one pot approach has led to the successful synthesis of the drug lead molecule, ataluren, 3-(5-(2-fluorophenyl)-1,2,4- oxadiazol-3-yl) benzoic acid in two steps. the Partner Organisations 2014.

A convenient synthesis of 5- and 6-substituted 2-phenyl-3H-pyrimidin-4-ones

A simple and convenient one-pot procedure for the synthesis of 5- and 6-substituted 2-phenyl-3H-pyrimidin-4-ones by the condensation of 4-alkoxy-1,1,1-trichloroalk-3-en-2-ones with benzamidine hydrochloride is described. Georg Thieme Verlag Stuttgart.

Ueber die Herstellung von Styryl- und Stylbenyl-Derivaten des Pyrimidins

2- and 4-(p-Tolyl)-substituted pyrimidines react with anils of hetero-aromatic aldehydes in the presence of dimethylformamide and potassium hydroxide or potassium t-butoxide to yield the corresponding 2- and 4-pyrimidines or