77252-67-6Relevant academic research and scientific papers
New nicotinic acid-based 3,5-diphenylpyrazoles: design, synthesis and antihyperlipidemic activity with potential NPC1L1 inhibitory activity
Shoman, Mai E.,Aboelez, Moustafa O.,Shaykhon, Montaser Sh. A.,Ahmed, Sanaa A.,Abuo-Rahma, Gamal El-Din A.,Elhady, Omar M.
, p. 673 - 686 (2020/02/25)
Nicotinic acid hydrazide was incorporated into new 4,5-dihydro-5-hydroxy-3,5-diphenylpyrazol-1-yl derivatives. Compounds 6a–h were synthesized, and their antihyperlipidemic activity was evaluated in high cholesterol diet-fed rat model. Compounds 6e, 6f were found to decrease the levels of serum total cholesterol by 14–19% compared to control group. Total triglycerides were also reduced by 24–28% and LDL cholesterol by 16%. As expected from parent niacin, compounds 6e and 6f caused an elevation of HDL cholesterol by 33–41%. Docking study supported the ability of designed compounds to block NPC1L1 active site in a manner similar to that observed with ezetimibe.
Modular access to 1,2-allenyl ketones based on a photoredox-catalysed radical-polar crossover process
Du, Chan,Fang, Jianghua,Fang, Yewen,Lei, Wan,Li, Yan,Liu, Yongjun
, p. 8502 - 8506 (2021/10/20)
Herein, a new protocol dealing with the preparation of 1,2-allenyl ketones has been successfully developedviathe reactions of enynes with radicals enabled by dual photoredox/copper catalysis. Based on the results of a deuteration experiment and the competition reaction between cyclopropanation and allenation, the mechanism based on a photoredox-neutral-catalysed radical-polar crossover process has been proposed. Synthetic applications of allenes have also been demonstrated.
Visible-light photoredox catalysis enabled bromination of phenols and alkenes
Zhao, Yating,Li, Zhe,Yang, Chao,Lin, Run,Xia, Wujiong
, p. 622 - 627 (2014/04/17)
A mild and efficient methodology for the bromination of phenols and alkenes has been developed utilizing visible light-induced photoredox catalysis. The bromine was generated in situ from the oxidation of Br- by Ru(bpy)33+, both of which resulted from the oxidative quenching process.
Microwave-assisted dehalogenation of α-haloketones by zinc and ammonium chloride in alcohol
Li, Jian,Ye, Deju,Liu, Hong,Luo, Xiaoming,Jiang, Hualiang
, p. 567 - 575 (2008/04/12)
The treatment of α-haloketones with 1.5 equiv. of Zn and 1 equiv. of NH4Cl in ethanol for 0.5αmin gave the corresponding ketones with excellent yields under microwave irradiation. Vic-dibromides and 2,2-dibromoacetophenone can be efficiently debrominated to alkenes and acetophenones, respectively. Copyright Taylor & Francis Group, LLC.
AZIRIDINYL KETONES AND THEIR CYCLIC ANILS. II. FLUORINE-CONTAINING PHOTOCHROMES
Orlov, V. D.,Vorob'eva, N. P.,Tishchenko, A. A.,Pikalev, O. M.,Popov, V. I.,Yagupol'skii, L. M.
, p. 942 - 946 (2007/10/02)
Chalcones with fluorine-containing groups were converted to α,β-dibromides and then to cyclic aziridinyl anils.The introduction of an electron-acceptor trifluoromethylsulfonyl group leads to a significant, although smaller as compared with the nitro group
