77267-14-2Relevant academic research and scientific papers
A Survey of the Borrowing Hydrogen Approach to the Synthesis of some Pharmaceutically Relevant Intermediates
Leonard, John,Blacker, A. John,Marsden, Stephen P.,Jones, Martin F.,Mulholland, Keith R.,Newton, Rebecca
, p. 1400 - 1410 (2015/11/02)
The use of the "borrowing hydrogen strategy" in the synthesis of a number of typical pharmaceutical intermediates has been investigated. The main aim of this work was to investigate the scope and limitations of current methodology using standard laboratory techniques in an industrial context. Some interesting and significant results were achieved across a diverse set of complex substrates; however several drawbacks with this approach were identified, such as the high loading, poor turnover, and susceptibility to substrate inactivation of the catalysts. These are areas which are highlighted for future investigation and improvements.
Synthesis and biological activity of benzotriazole derivatives structurally related to trazodone
Caliendo, G.,Carlo, R. Di,Greco, G.,Meli, R.,Novellino, E.,et al.
, p. 77 - 84 (2007/10/02)
This paper outlines the synthesis and the pharmacological screening of a series of novel 1- and 2-ethyl>benzotriazoles and 1-propoxy>benzotriazoles, which are structurally related to trazodone.Antiserotonergic, antiadrenergic and antihistaminic in vitro activity and in vivo analgesic action are described.Some of the investigated compounds show overall pharmacological profiles similar to that of the antidepressant trazodone. benzotriazole / antiserotonergic activity / antiadrenergic activity / antihistaminic activity / analgesic activity
