77284-64-1

Usage

Uses

Used in Pharmaceutical Industry:
BOC-DL-2-aminobutyric acid is used as a chiral building block for the production of pharmaceuticals. Its controlled release in peptide synthesis allows for the development of complex and specific drug molecules with targeted therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical industry, BOC-DL-2-aminobutyric acid is utilized as a chiral building block for the synthesis of agrochemicals. Its controlled release in peptide synthesis contributes to the development of effective and targeted agrochemicals for crop protection and enhancement.
Used in Materials Science:
BOC-DL-2-aminobutyric acid is employed as a chiral building block in materials science. Its controlled release in peptide synthesis aids in the development of advanced materials with specific properties and applications.
Used in Organic Synthesis:
BOC-DL-2-aminobutyric acid is used as an important intermediate in organic synthesis. Its unique structure and controlled release properties enable the synthesis of a wide range of organic compounds, including new drugs and bioactive molecules.
Used in Peptide Synthesis:
BOC-DL-2-aminobutyric acid is used as a biochemical reagent in peptide synthesis. Its t-butoxycarbonyl protecting group allows for controlled release of the amino group, facilitating the stepwise assembly of peptide chains with high precision and selectivity. This contributes to the development of peptides with specific functions and applications in various fields, such as medicine, biotechnology, and research.

InChI:InChI=1/C9H17NO4/c1-5-6(7(11)12)10-8(13)14-9(2,3)4/h6H,5H2,1-4H3,(H,10,13)(H,11,12)/p-1/t6-/m1/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 40522-79-0 2-aminobutyric acid hydrochloride 
• 2835-81-6 2-aminobutanoic acid 

Downstream Products

• 145280-04-2 (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>butanoate 
• 145280-03-1 (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (R)-2-<(tert-butoxycarbonyl)amino>butanoate 
• 162126-54-7 (R)-2-(t-butoxycarbonylamino)-N-phenyl-butanamide 
• 58561-08-3 methyl N-(tert-butoxycarbonyl)-2-aminobutyrate 
• 34306-42-8 Boc-Abu 
• 1403942-29-9 (S)-tert-butyl 1-oxo-1-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)butan-2-ylcarbamate 
• 1397708-99-4 C₂₃H₂₈N₄O₄ 
• 1333404-63-9 C₂₁H₂₅N₃O₃S 
• 786652-81-1 [1-(1-methyl-2-oxo-2-phenyl-ethylcarbamoyl)-propyl]carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Enantioselective Deaminative Alkylation of Amino Acid Derivatives with Unactivated Olefins

Herein, we report the first Ni-catalyzed enantioselective deaminative alkylation of amino acid and peptide derivatives with unactivated olefins. Key for success was the discovery of a new sterically encumbered bis(oxazoline) ligand backbone, thus offering a de novo technology for accessing enantioenriched sp3-sp3 linkages via sp3 C-N functionalization. Our protocol is distinguished by its broad scope and generality across a wide number of counterparts, even in the context of late-stage functionalization. In addition, an enantioselective deaminative remote hydroalkylation reaction of unactivated internal olefins is within reach, thus providing a useful entry point for forging enantioenriched sp3-sp3 centers at remote sp3 C-H sites.

Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection

Due to the increased morbidity and mortality by fungal infections and the emergence of severe antifungal resistance, there is an urgent need for new antifungal agents. Here, we screened for antifungal activity in our in-house library through the minimum inhibitory concentration test and derived two hit compounds with moderate antifungal activities. The hit compounds' antifungal activities and drug-like properties were optimized by substituting various aryl ring, alkyl chain, and methyl groups. Among the optimized compounds, 22h was the most promising candidate with good drug-like properties and exhibited potent fast-acting fungicidal antifungal effects against various fungal pathogens and synergistic antifungal activities with some known antifungal drugs. Additionally, 22h was further confirmed to disturb fungal cell wall integrity by activating multiple cell wall integrity pathways. Furthermore, 22h exerted significant antifungal efficacy in both the subcutaneous infection mouse model and ex vivo human nail infection model.

FUNCTIONAL DERIVATIVE COMPOUNDS OF ALANINE AND PROLINE AMINO ACIDS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to novel functional derivatives of alanine and proline amino acids. The compounds of the present invention were confirmed to have a very superior antifungal or fungicidal effect. In addition, the compounds of the present inve

HETEROARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSTION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH PI3 KINASES, CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a heteroaryl derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition for preventing or treating diseases associated with PI3 kinases, containing the same as an active ingredient. The heteroaryl derivative according to the present invention has an excellent effect of selectively inhibiting PI3 kinases, thereby being useful in preventing or treating PI3 kinase diseases such as: cancers, autoimmune diseases, and respiratory diseases.

Bioproduction of l-2-Aminobutyric Acid by a Newly-Isolated Strain of Aspergillus tamarii ZJUT ZQ013

Abstract: l-2-Aminobutyric acid (l-ABA), an unnatural amino acid, is a key intermediate of several important drugs. Although some methods have been developed to prepare pure chiral l-ABA, there are still many drawbacks, including low catalytic efficiency, cumbersome steps and high cost due to the addition of some expensive catalysts or coenzymes. Herein, with chemical and biological approaches together, we discovered a newly isolated Aspergillus tamarii ZJUT ZQ013 strain containing a microbial lipase which could be employed to resolve racemic methyl N-Boc-2-aminobutyrate to produce l-ABA with high enantioselectivity (e.e.s?>?99.9%, E = 257). Moreover, the subsequent gram scale experiment confrimed that A. tamarii ZJUT ZQ013 could be an attractive biocatalyst for the efficient preparation of optically pure acid. Graphical Abstract: [Figure not available: see fulltext.]