77284-64-1

Basic information

• Product Name: BOC-DL-2-AMINOBUTYRIC ACID
• Synonyms: 2-Aminobutanoic acid, N-BOC protected;Boc-2-aMinobutyric acid;2-(tert-butoxycarbonyl)butanoic acid;BOC-DL-2-AMINOBUTYRIC ACID;2-[(tert-Butoxycarbonyl)amino]butanoic acid;Boc-DL-2-Abu;DL-Boc-Aminobutyric acid
• CAS NO: 77284-64-1
• Molecular Formula: C₉H₁₇NO₄
• Molecular Weight: 203.24
• Product Categories: pharmacetical
• Mol File: 77284-64-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 60-62 °C
• Boiling Point: 334.5°C at 760 mmHg
• Flash Point: 156.1°C
• Appearance: /
• Density: 1.101±0.06 g/cm3(Predicted)
• Vapor Pressure: 2.42E-05mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.00±0.10(Predicted)
• CAS DataBase Reference: BOC-DL-2-AMINOBUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-DL-2-AMINOBUTYRIC ACID(77284-64-1)
• EPA Substance Registry System: BOC-DL-2-AMINOBUTYRIC ACID(77284-64-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 77284-64-1(Hazardous Substances Data)

Usage

General Description

BOC-DL-2-aminobutyric acid, also known as tert-butyl (S)-2-aminobutyrate, is a chemical compound used in peptide synthesis and as a biochemical reagent. It is an amino acid derivative with a t-butoxycarbonyl (BOC) protecting group attached to the amino group, which allows for controlled release in peptide synthesis. BOC-DL-2-aminobutyric acid is used as a chiral building block in the production of pharmaceuticals, agrochemicals, and materials science. It is an important intermediate in organic synthesis and has applications in the development of new drugs and bioactive molecules.

InChI:InChI=1/C9H17NO4/c1-5-6(7(11)12)10-8(13)14-9(2,3)4/h6H,5H2,1-4H3,(H,10,13)(H,11,12)/p-1/t6-/m1/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 2835-81-6 2-aminobutanoic acid 
• 40522-79-0 2-aminobutyric acid hydrochloride 

Downstream Products

• 786652-81-1 [1-(1-methyl-2-oxo-2-phenyl-ethylcarbamoyl)-propyl]carbamic acid tert-butyl ester 
• 58561-08-3 methyl N-(tert-butoxycarbonyl)-2-aminobutyrate 
• 34306-42-8 Boc-Abu 
• 1403942-29-9 (S)-tert-butyl 1-oxo-1-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)butan-2-ylcarbamate 
• 1397708-99-4 C₂₃H₂₈N₄O₄ 
• 1333404-63-9 C₂₁H₂₅N₃O₃S 
• 162126-54-7 (R)-2-(t-butoxycarbonylamino)-N-phenyl-butanamide 
• 145280-04-2 (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>butanoate 
• 145280-03-1 (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (R)-2-<(tert-butoxycarbonyl)amino>butanoate 

Relevant articles and documents

Enantioselective Deaminative Alkylation of Amino Acid Derivatives with Unactivated Olefins

Herein, we report the first Ni-catalyzed enantioselective deaminative alkylation of amino acid and peptide derivatives with unactivated olefins. Key for success was the discovery of a new sterically encumbered bis(oxazoline) ligand backbone, thus offering a de novo technology for accessing enantioenriched sp3-sp3 linkages via sp3 C-N functionalization. Our protocol is distinguished by its broad scope and generality across a wide number of counterparts, even in the context of late-stage functionalization. In addition, an enantioselective deaminative remote hydroalkylation reaction of unactivated internal olefins is within reach, thus providing a useful entry point for forging enantioenriched sp3-sp3 centers at remote sp3 C-H sites.

FUNCTIONAL DERIVATIVE COMPOUNDS OF ALANINE AND PROLINE AMINO ACIDS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to novel functional derivatives of alanine and proline amino acids. The compounds of the present invention were confirmed to have a very superior antifungal or fungicidal effect. In addition, the compounds of the present inve

Bioproduction of l-2-Aminobutyric Acid by a Newly-Isolated Strain of Aspergillus tamarii ZJUT ZQ013

Abstract: l-2-Aminobutyric acid (l-ABA), an unnatural amino acid, is a key intermediate of several important drugs. Although some methods have been developed to prepare pure chiral l-ABA, there are still many drawbacks, including low catalytic efficiency, cumbersome steps and high cost due to the addition of some expensive catalysts or coenzymes. Herein, with chemical and biological approaches together, we discovered a newly isolated Aspergillus tamarii ZJUT ZQ013 strain containing a microbial lipase which could be employed to resolve racemic methyl N-Boc-2-aminobutyrate to produce l-ABA with high enantioselectivity (e.e.s?>?99.9%, E = 257). Moreover, the subsequent gram scale experiment confrimed that A. tamarii ZJUT ZQ013 could be an attractive biocatalyst for the efficient preparation of optically pure acid. Graphical Abstract: [Figure not available: see fulltext.]