145280-04-2

Basic information

• Product Name: (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>butanoate
• Synonyms: (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>butanoate
• CAS NO: 145280-04-2
• Molecular Weight: 417.589
• Mol File: 145280-04-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>butanoate(145280-04-2)
• EPA Substance Registry System: (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>butanoate(145280-04-2)

Safety Data

• Hazardous Substances Data: 145280-04-2(Hazardous Substances Data)

Upstream product

• 117049-08-8 (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl<(tert-butoxycarbonyl)amino>bromoacetate 
• 65253-04-5 (-)-8-phenylmenthol 
• 4530-20-5 BOC-glycine 
• 940350-32-3 (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (R,S)-2-<(tert-butoxycarbonyl)amino>but-3-enoate 
• 925-90-6 ethylmagnesium bromide 
• 77284-64-1 N-(tert-butoxycarbonyl)-2(S)-aminobutyric acid 

Relevant articles and documents

The asymmetric synthesis of α-amino acids via the addition of grignard reagents to imine derivatives

The ester-8-phenylmenthyl N-Boc-glycinate 5a, undergoes free radical bromination by N-bromosuccinimide to give 8-phenylmenthyl N-Boc-bromoglycinate 8. Treatment of the bromide 8 with a variety of Grignard reagents at low temperature gave 8-phenylmenthyl (S-N-Boc-2-alkylgrycinates with high diastereoselectivity. Conditions were found for the hydrolysis of these derivatives with no racemization of the resultant amino acid.