77285-09-7

Basic information

• Product Name: AC-SER(TBU)-OH
• Synonyms: ACETYL-O-T-BUTYL-L-SERINE;AC-L-SER(TBU)-OH;AC-SERINE(TBU)-OH;AC-SER(TBU)-OH;N-ALPHA-ACETYL-O-T-BUTYL-L-SERINE;N-ACETYL-O-TERT-BUTYL-L-SERINE;N-ACETYL-O-T-BUTYL-L-SERINE;N-alpha-Actetyl-O-t-butyl-L-serine
• CAS NO: 77285-09-7
• Molecular Formula: C9H17NO4
• Molecular Weight: 203.24
• EINECS: 200-528-9
• Product Categories: Amino Acids and Derivatives
• Mol File: 77285-09-7.mol
• Article Data: 4

Chemical Properties

• Appearance: White/Crystalline Powder
• Storage Temp.: -15°C
• CAS DataBase Reference: AC-SER(TBU)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: AC-SER(TBU)-OH(77285-09-7)
• EPA Substance Registry System: AC-SER(TBU)-OH(77285-09-7)

Safety Data

• Hazardous Substances Data: 77285-09-7(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Upstream product

• 18822-58-7 (S)-O-tert-butylserine 
• 108-24-7 acetic anhydride 
• 2104-89-4 D-serine methyl ester 
• 86852-11-1 diethoxyltriphenylphosphorane 
• 75-65-0 tert-butyl alcohol 

Relevant articles and documents

Synthesis and bioactivity of a Goralatide analog with antileukemic activity

Natural tetrapeptide Goralatide (AcSDKP) is a selective inhibitor of primitive haematopoietic cell proliferation. It is not stable in vivo and decomposes within 4.5 min when applied to live cells. In this work we developed an analog of Goralatide that exhibits cytotoxicity towards human myeloid HL-60, HEL, Nalm-6 leukemia cells, endothelial HUVEC, glioblastoma U251 and transformed kidney 293T cells. The Goralatide analog showed significant stability in organic solution with no tendency to degrade oxidatively.

Synthesis of L-Lys-Aminoxy-Goralatide

Natural tetrapeptide Goralatide inhibits primitive hematopoietic cell proliferation but reported to be rather unstable in solution (half-life 4.5min). In this work, we report the synthesis of an aminoxy analog of Goralatide. Aminoxy moiety is expected to