77290-48-3Relevant academic research and scientific papers
Synthesis of 7-Chloro-L- and 7-Chloro-D-tryptophan; Biosynthesis of Pyrrolnitrin
Pee, Karl-Heinz van,Salcher, Olga,Lingens, Franz
, p. 233 - 239 (2007/10/02)
The article describes the synthesis of 7-chloro-DL-tryptophan (1 with R=Cl) via the intermediates 5, 6, 7 and 8.The separation of the optical antipodes was achieved by treatment of 7-chloro-N-chloroacetyl-DL-tryptophan (9) with carboxypeptidase.DL-Tryptophan (1 with R=H), 1 with R=Cl and its anomers, 1a with R=Cl and 1b with R=Cl, are substrates of L-tryptophan-2,3-dioxygenase from Pseudomonas aureofaciens.
