77301-68-9

Upstream product

• 77301-61-2 (E)-2-Methyl-3-phenyl-<3-D>-2-propen-1-ol 
• 77301-60-1 (E)-2-Methyl-3-phenyl-<3-D>propenal 
• 3592-47-0 Benzaldehyde-d 
• 124-38-9 carbon dioxide 
• 77301-65-6 <3-D>-2,2-Dichlor-1-methyl-3-phenyl-1-cyclopropanmethanol-tetrahydro-2-pyranylether 

Downstream Products

• 77301-70-3 1-tert-Butoxy-2c-hydroxymethyl-2t-methyl-3c-phenyl-1r-cyclopropancarbonsaeure-lacton 
• 77308-68-0 1-tert-Butoxy-2c-hydroxymethyl-2t-methyl-3c-phenyl-<3t-D>-1r-cyclopropancarbonsaeure-lacton 

Relevant academic research and scientific papers

Mechanism of the Substitution at the Cyclopropane Ring

Starting from 2a the bicyclic chlorolactone 14a is obtained via 3a and 11a.Reaction of 14a with KOtBu gives the lactone 17b which also is formed from 14b.These results can be explained by a mechanism via the intermediate E.Additional evidence is given by the failure of 15a and b to react with KOtBu and by the product distribution of the reaction of deuterated compound 16a.