773050-52-5

Upstream product

• 7697-28-1 4-bromo-3-methylbenzoic acid 
• 808125-97-5 2-[4-(2-bromo-5-tert-butoxycarbonylbenzyloxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 
• 503859-17-4 2-bromo-5-(tert-butoxycarbonyl)benzyl bromide 
• 347174-28-1 tert-butyl 4-bromo-3-methylbenzoate 
• 808125-98-6 2-[4-(4-tert-butoxycarbonyl-4'-chloro-biphen-2-ylmethoxy)-2-fluoro-phenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 

Downstream Products

• 905459-76-9 2-[4-(4'-chloro-4-chlorocarbonyl-biphenyl-2-ylmethoxy)-2-fluoro-phenyl]-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid methyl ester 
• 347173-91-5 2-[4-(4-methylcarbamoyl-4'-chlorobiphenyl-2-ylmethoxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 
• 347173-80-2 methyl 2-{4-[2-(4-chlorophenyl)-5-(dimethylcarbamoyl)benzyloxy]-2-fluorophenyl}-1-cyclohexylbenzimidazole-5-carboxylate 
• 808126-00-3 2-{4-(4'-chloro-4-(hydroxyl-piperidine-1-carbonyl)-biphen-2-ylmethoxy)-2-fluoro-phenyl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: Structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109

Following the discovery of a new series of benzimidazole derivatives bearing a diarylmethyl group as inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase (HCV NS5B RdRp), we extended the structure-activity relationship (SAR) study to analogue

NITROGEN-CONTAINING HETEROARYL DERIVATIVES

Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.