77307-62-1Relevant academic research and scientific papers
SYNTHESES OF 2-HYDROXYMETHYL-4(3H)-QUINAZOLINONE AND ITS ANALOGS
Ishikawa, Masayuki,Eguchi, Yukuo
, p. 31 - 34 (2007/10/02)
The syntheses of 6-ethoxycarbonyl-2-hydroxymethyl-5,7-dimethyl-4(3H)-quinazolinone, 7-(or 6-)-ethoxycarbonyl-2,6,8-(or 2,5,7-)-trimethyl-3-phenyl-4(3H)-quinazolinone were described.The 3-phenyl-4(3H)-quinazolinone compounds were further converted to the corresponding 2-hydroxymethyl derivative.The starting compounds, 2-amino-4-ethoxycarbonyl-3,5-dimethylbenzoic acid and 2-amino-5-ethoxycarbonyl-4,6-dimethylbenzoic acid were prepared by the Hofmann reaction of the corresponding phthalimide.
