77307-63-2

Upstream product

• 768368-41-8 4-acetoxyacetylamino-2,6-dimethyl-1,3-benzenedicarboxylic acid 1-ethyl ester 
• 62-53-3 aniline 
• 67467-27-0 2-amino-5-ethoxycarbonyl-4,6-dimethylbenzoic acid 
• 127-09-3 sodium acetate 
• 77307-62-1 2-bromomethyl-6-ethoxycarbonyl-5,7-dimethyl-3-phenyl-4(3H)-quinazolinone 

Relevant academic research and scientific papers

A facile synthesis of C2N3-disubstituted-4- quinazolone

A simple and efficient methodology for the synthesis of C 2,N3-disubstituted-4 quinazolones from anilines and N-acylanthranilic acids was developed. The new cyclization conditions are much milder than any other reported protocols and

SYNTHESES OF 2-HYDROXYMETHYL-4(3H)-QUINAZOLINONE AND ITS ANALOGS

The syntheses of 6-ethoxycarbonyl-2-hydroxymethyl-5,7-dimethyl-4(3H)-quinazolinone, 7-(or 6-)-ethoxycarbonyl-2,6,8-(or 2,5,7-)-trimethyl-3-phenyl-4(3H)-quinazolinone were described.The 3-phenyl-4(3H)-quinazolinone compounds were further converted to the corresponding 2-hydroxymethyl derivative.The starting compounds, 2-amino-4-ethoxycarbonyl-3,5-dimethylbenzoic acid and 2-amino-5-ethoxycarbonyl-4,6-dimethylbenzoic acid were prepared by the Hofmann reaction of the corresponding phthalimide.