773092-05-0 Usage
Uses
Used in Pharmaceutical Industry:
Ym-443 is used as a prokinetic agent for the treatment of functional dyspepsia. It is effective in reducing postprandial fullness, upper abdominal bloating, and early satiation by enhancing gastric emptying and accommodation.
Used in Drug Development:
Ym-443 is used in the development of a synthetic route that employs pyridine hydrochloride to selectively cleave a 2-substituted methyl ether from a 2,4,5-trimethoxy benzamide intermediate, as a key step. This synthetic route has been reported to improve the production of acotiamide.
Brand Name:
Acofide Trihydrate
Originator
Zeria Pharmaceutical (Japan)
Synthesis
Commercial 3,4,5-trimethoxybenzoic acid was first converted
to the corresponding acid chloride, which was isolated
by co-distillation with hexane. In refluxing dichloroethane (DCE),
the acid chloride was coupled with the commercially available
thiazole amine to give the desired amidothiazole in 89% yield.
From this intermediate, amide linkage, selective demethylation of
the 2-methoxy group, salt formation, and recrystallization were
accomplished in the following sequence: the thiazole ester was
reacted with N,N-diisopropyl ethylenediamine in DMA at elevated
temperatures. Upon cooling, the mixture was dissolved in
n-butanol and washed with aqueous sodium hydroxide.
Subsequent treatment with HCl gas in isopropanol gave the
corresponding HCl salt as crystals that could be collected by filtration.
The product obtained was further crystallized from 4:1 isopropanol
and water to give the desired product acotimide (I) as
the hydrochloride trihydrate in 71% yield.
Check Digit Verification of cas no
The CAS Registry Mumber 773092-05-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,7,3,0,9 and 2 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 773092-05:
(8*7)+(7*7)+(6*3)+(5*0)+(4*9)+(3*2)+(2*0)+(1*5)=170
170 % 10 = 0
So 773092-05-0 is a valid CAS Registry Number.
