77312-66-4

Usage

Uses

4-Demethoxy-11-deoxydaunorubicin is an antitumor anthracycline daunomycin.

InChI:InChI=1/C26H27NO8/c1-11-22(29)17(27)8-19(34-11)35-18-10-26(33,12(2)28)9-13-7-16-21(25(32)20(13)18)24(31)15-6-4-3-5-14(15)23(16)30/h3-7,11,17-19,22,29,32-33H,8-10,27H2,1-2H3

Upstream product

• 60660-74-4 (+)-N-Trifluoroacetyl-4-demethoxydaunorubicin 
• 57852-57-0 idarubicin hydrochloride 

Relevant academic research and scientific papers

Stable and safe idarubicin pharmaceutical composition and preparation method thereof

The invention discloses a stable and safe idarubicin pharmaceutical composition and a preparation method thereof. The pharmaceutical composition contains idarubicin or a pharmaceutically acceptable salt thereof and a compound of formula A or a pharmaceutically acceptable salt thereof in an amount of no more than 0.3%. According to the method, an impurity A in idarubicin is separated and confirmed.Prior to this, there is no report that the impurity A is present in the idarubicin. The impurity A is fully researched, it is found that the existence of the impurity A affects the physical and chemical stability of idarubicin and increases cardiac toxicity of idarubicin. The pharmaceutical composition enables idarubicin to maintain good stability. The invention further provides a method for preparing the impurity A. The high-purity impurity A can be acquired to serve as a reference sample or a standard sample for controlling the content of the impurity A in idarubicin and preparations thereof.