773136-70-2

Usage

Uses

Used in Chemical Synthesis:
1H-Pyrazole-5-carboxylic acid, 1,3,4-trimethyl-, methyl ester (9CI) is used as a key intermediate in the preparation of 3-(1,3,4-trimethylpyrazol-5-yl)acrylonitrile derivatives. These derivatives are important in the synthesis of various chemical compounds, including pharmaceuticals and agrochemicals, due to their unique reactivity and structural properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1H-Pyrazole-5-carboxylic acid, 1,3,4-trimethyl-, methyl ester (9CI) is used as a building block for the development of new drugs. Its unique chemical structure allows for the creation of novel compounds with potential therapeutic applications, such as anti-inflammatory, analgesic, and anti-cancer agents.
Used in Agrochemical Industry:
1H-Pyrazole-5-carboxylic acid, 1,3,4-trimethyl-, methyl ester (9CI) is also utilized in the agrochemical industry for the synthesis of new pesticides and herbicides. Its versatile chemical properties enable the development of innovative compounds with improved efficacy and selectivity, contributing to more sustainable agricultural practices.

Upstream product

• 60858-33-5 4,5-dimethyl-1⁽²⁾H-pyrazole-3-carboxylic acid methyl ester 
• 74-88-4 methyl iodide 
• 10250-59-6 1,3-dimethyl-1H-pyrazole-5-carboxylic acid methyl ester 
• 25016-17-5 3-methyl-1H-pyrazole-5-carboxylic acid methyl ester 
• 20577-61-1 methyl 2,4-dioxopentanoate 
• 553-90-2 Dimethyl oxalate 
• 60-34-4 methylhydrazine 
• 78-93-3 butanone 

Relevant academic research and scientific papers

Preparation method of 3, 4-dimethylpyrazole-5-formate compound

The invention provides a preparation method of a 3, 4-dimethylpyrazole-5-formate compound. According to the method, 2-butanone and oxalic acid diester serve as raw materials, a 3-methyl acetylacetonate compound is prepared in a high-yield and high-regioselectivity mode under the catalysis of an organic annular secondary amine catalyst, the 3-methyl acetylacetonate compound reacts with hydrazine, and the 3, 4-dimethylpyrazole-5-formate compound is prepared in a high-yield mode. According to the preparation method, organic nitrogen-containing cyclic secondary amine compounds such as pyrroline, piperidine and morpholine are used as catalysts, and alcohols such as methanol and ethanol are used as solvents for reaction. The method has the characteristics of relatively mild reaction conditions, simplicity and convenience in operation, high regioselectivity, high yield and the like, and the synthesized 3, 4-dimethylpyrazole-5-formate compound can be used for preparing cyenopyrafen acaricides.

Synthesis, Acaricidal Activity, and Structure-Activity Relationships of Pyrazolyl Acrylonitrile Derivatives

A series of novel pyrazolyl acrylonitrile derivatives was designed, targeting Tetranychus cinnabarinus, and synthesized. Their structures were identified by combination of1H NMR,13C NMR, and MS spectra. The structures of compounds 18 and 19 were further confirmed by X-ray diffraction. Extensive greenhouse bioassays indicated that compound 19 exhibits excellent acaricidal activity against all developmental stages of T. cinnabarinus, which is better than the commercialized compounds cyenopyrafen and spirodiclofen. It was shown that the acute toxicity of compounds 19 to mammals is quite low. The structure-activity relationships are also discussed.