77318-13-9Relevant academic research and scientific papers
Synthesis method of aryl-substituted homoallylic alcohol
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Paragraph 0061-0065; 0089-0090, (2019/05/08)
The invention relates to compound preparation, belongs to the field of organic synthesis and discloses a synthesis method of aryl-substituted homoallylic alcohol. An aryl boron compound and alkenyl epoxy serve as raw materials to react in a solvent under
Synthesis and evaluation of novel alkylpiperazines as potential dopamine antagonists
Glennon,Salley Jr.,Steinsland,Nelson
, p. 678 - 683 (2007/10/02)
Several alkylpiperazines, monocyclic subfragments of known tricyclic neuroleptic agents, were evaluated as dopamine antagonists in the isolated rabbit ear artery preparation. Compounds prepared and evaluated are of the general structure Ar-X-(CH2)(n)-Y, where X = C, O, and N, n = 1-3, and Y, for the most part, was 4-methylpiperazine. Those compounds where X = NH, n = 3, and X = (Z)-CH=CH, n = 2, with an electron-witdrawing group meta to the side chain, possess dopamine antagonist activity comparable to that of clozapine. It is concluded that the entire tricyclic structure of phenothiazine-like agents (or at least more than a monocyclic ring system) is necessary for optimal activity as a dopamine antagonist in the receptor preparation used in this study.
