77326-46-6 Usage
Uses
Used in Pharmaceutical Industry:
Methyl 2-cyano-3-nitrobenzoate is used as a key intermediate in the synthesis of various pharmaceuticals. Its strong nitro and cyano substituents enable the formation of carbon-carbon and carbon-heteroatom bonds, which are essential for the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, Methyl 2-cyano-3-nitrobenzoate is employed as a building block for the preparation of various agrochemicals. Its versatile reactivity allows for the synthesis of compounds with potential applications in crop protection, pest control, and other agricultural practices.
Used in Dye Industry:
Methyl 2-cyano-3-nitrobenzoate is used as a starting material for the production of various dyes. Its unique chemical structure allows for the creation of dyes with specific color properties and stability, making it valuable in the dye industry.
Used in Plastics, Resins, and Polymers Manufacturing:
Methyl 2-cyano-3-nitrobenzoate is utilized in the manufacturing of high-quality plastics, resins, and polymers. Its strong nitro and cyano substituents contribute to the development of materials with enhanced properties, such as improved strength, durability, and resistance to environmental factors.
Safety Considerations:
Due to the potential toxic and harmful effects of Methyl 2-cyano-3-nitrobenzoate, it is crucial to follow safety guidelines when working with Methyl 2-cyano-3-nitrobenzoate. Proper handling, storage, and disposal measures should be implemented to minimize the risk of exposure and ensure the safety of individuals involved in its production and use.
Check Digit Verification of cas no
The CAS Registry Mumber 77326-46-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,3,2 and 6 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 77326-46:
(7*7)+(6*7)+(5*3)+(4*2)+(3*6)+(2*4)+(1*6)=146
146 % 10 = 6
So 77326-46-6 is a valid CAS Registry Number.
77326-46-6Relevant academic research and scientific papers
Antifolate and Antibacterial Activities of 5-Substituted 2,4-Diaminoquinazolines
Harris, Neil V.,Smith, Christopher,Bowden, Keith
, p. 434 - 444 (2007/10/02)
A series of 5-substituted 2,4-diaminoquinazolines (3) has been synthesized and evaluated as inhibitors of the enzyme dihydrofolate reductase (DHFR) from both bacterial and mammalian sources.The best compounds (e.g. 53) show good activity against Escherichia coli DHFR, but there is no significant selectivity for the bacterial over the mammalian enzyme.The structure-activity relationships for enzyme inhibition appear to be complex and not amenable to simple analysis; a hypotesis to explain the observed qualitative structure-activity relationships is proposed.The inhibitory activities of the compounds against the growth of intact bacterial cells in vitro closely parallel those for the inhibition of the isolated bacterial enzymes, suggesting that their antifolate action is responsible for their antibacterial effects.Five of the compounds were tested for their ability to cure a systemic E. coli infection in the mouse, but they showed no therapeutic effects at their maximum tolerated doses.
N-(Aminophenyl)oxamic Acids and Esters as Potent, Orally Active Antiallergy Agents
Klaubert, Dieter H.,Sellstedt, John H.,Guinosso, Charles J.,Capetola, Robert J.,Bell, Stanley C.
, p. 742 - 748 (2007/10/02)
A series of N-(2-cyano-substituted-phenyl)oxamates was prepared by acylation of the appropriate anthranilonitrile with ethyloxalyl chloride.Hydrolysis with sodium hydroxide gave the corresponding oxamic acid sodium salts.These compounds were extremely potent when tested in the rat passive cutaneous anaphylaxis (PCA assay either by the ip or the po route of administration).One of the sodium salts, oxoacetic acid sodium salt (11a, Wy-41 195), has ED50 value of 0.07 mg/kg po and has been selected for further evaluation.
