77349-94-1Relevant academic research and scientific papers
Synthesis and insulin-sensitizing activity of (S)-2-ethoxy-3- phenylpropanoic acid derivatives
Cai, Xiao-Hua,Xie, Bing
, p. 1106 - 1109 (2007/10/03)
A series of (S)-2-ethoxy-3-phenylpropanoic acid derivatives were synthesized and their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Compounds 1b (EC30 = 9.43 × 10-3 μmol/L), 1d (EC30 = 7.45 × 10-3 μmol/L), 1e (EC 30 = 6.22 × 10-3 μmol/L), and 1f (EC30 = 7.76 × 10-3 μmol/L) exhibited more potent insulin-sensitizing activity than rosiglitazone (EC30 = 2.06 × 10-2 μmol/L).
Synthesis and evaluation of methyl 2-methoxycarbonyl-3-phenylpropionate derivatives as a new type of angiotensin converting enzyme inhibitors
Cai, Xiao-Hua,Xie, Bing,Guo, Hui
, p. 1110 - 1113 (2007/10/03)
Methyl 2-methoxycarbonyl-3-phenylpropionate derivatives were prepared, and their inhibitory activities for angiotensin converting enzyme (ACE) were evaluated. Compounds 5b (IC50 = 0.0039 μmol/L), 5d (IC 50 = 0.0027 μmol/L), 5e (IC50 = 0.0021 μmol/L), and 5f (IC50 = 0.0052 μmol/L) exhibited more potent ACE inhibitiory activity than the control drug Captopril (IC50 = 0.0075 μmol/L).
