4596-95-6

Upstream product

• 3478-90-8 4,4'-diphenylbenzophenone 
• 77349-94-1 4,4'-diphenyl-benzhydryl chloride 
• 67-64-1 acetone 
• 60-29-7 diethyl ether 
• 121260-99-9 tetrakis-biphenyl-4-yl-ethane-1,2-diol 
• 141-52-6 sodium ethanolate 
• 71-43-2 benzene 
• 873414-58-5 1,1-bis-biphenyl-4-yl-2,2-diphenyl-ethane-1,2-diol 
• 3901-32-4 bis(4-biphenylyl)methane 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 109-94-4 formic acid ethyl ester 
• 64-17-5 ethanol 
• 7732-18-5 water 
• 3315-91-1 4-biphenylylmagnesium bromide 

Downstream Products

• 4596-96-7 Di(4-biphenylyl)brommethan 
• 3478-90-8 4,4'-diphenylbenzophenone 
• 3901-32-4 bis(4-biphenylyl)methane 
• 71482-20-7 Benzoic acid bis-biphenyl-4-yl-methyl ester 
• 77349-94-1 4,4'-diphenyl-benzhydryl chloride 
• 922521-40-2 2-[(bis-biphenyl-4-yl-methyl)-methyl-amino]-ethanol 
• 922521-46-8 methanesulfonic acid 2-[(bis-biphenyl-4-yl-methyl)-methyl-amino]-ethyl ester 
• 14704-22-4 1,1,2,2-tetrakis-biphenyl-4-yl-ethane 
• 71482-15-0 4,4'-Diphenylbenzhydryl-phenylketon 
• 1355718-55-6 (di(1,1'-biphenyl-4-yl)methyl)triphenylphosphonium bromide 
• 1397678-19-1 3,6-diphenyl-9H-fluoren-9-one 

Relevant academic research and scientific papers

Large-scale synthesis of novel sterically hindered acenaphthene-based α-diimine ligands and their application in coordination chemistry

An efficient method to synthesize novel highly sterically hindered acenaphthene-based α-diimine ligands bearing bulky diarylmethyl moiety was achieved by two-step reactions. These reactions could be carried out on a scale of 100 g with no chromatography involved. On the basis of this method, a series of novel highly sterically hindered acenaphthene-based α-diimine Pd(II) and Ni(II) complexes, imidazolium precursors and the corresponding NHCs-metal complexes were also successfully synthesized. These novel complexes can offer great potential for metal-catalyzed polymerizations and organic reactions.

Synthesis of fluorenone derivatives through Pd-catalyzed dehydrogenative cyclization

Palladium-catalyzed dual C-H functionalization of benzophenones to form fluorenones by oxidative dehydrogenative cyclization is reported. This method provides a concise and effective route toward the synthesis of fluorenone derivatives, which shows outstanding functional group compatibility.

Facile preparation of aromatic esters from aromatic bromides with ethyl formate or DMF and molecular iodine via aryllithium

Various aromatic bromides were treated with n-BuLi and subsequently with ethyl formate, followed by the reaction with ethanol and molecular iodine in the presence of K2CO3 to provide the corresponding aromatic ethyl esters in good yields. Moreover, aromatic bromides could be transformed into the corresponding aromatic methyl esters in good yields by the treatment with n-BuLi and subsequently with DMF, followed by the reaction with methanol, molecular iodine, and K2CO3. Some aromatics could be also converted into the corresponding aromatic esters in good yields by the treatment with n-BuLi, and subsequently with ethyl formate or DMF, followed by the reaction with molecular iodine and K2CO3. The present reactions offer a novel route for the transition-metal-free, carbon-monoxide-free, and therefore environmentally benign one-pot conversion of aromatic bromides and aromatics into aromatic esters.

Synthesis and photoluminescent properties of new ceramidine derivatives

A series of new ceramidine derivatives 8a-f has been synthesized in 4-5 steps involving a Wittig reaction of ceramidonine with various triphenylphosphonium bromides. Their UV and photoluminescence (PL) properties are reported. The compounds showed medium to strong PL between 502 and 522 nm at a concentration of 1 × 10-5 M CH2Cl2.

Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17)-Part II: Core rigidification and influence of substituents at the methylene bridge

Thirty-five novel substituted imidazolyl methylene biphenyls have been synthesized as CYP17 inhibitors for the potential treatment of prostate cancer. Their activities have been tested with recombinant human CYP17 expressed in Escherichia coli. Promising compounds were tested for selectivity against CYP11B1, CYP11B2, and hepatic CYP enzymes 3A4, 1A2, 2B6 and 2D6. The core rigidified compounds (30-35) were the most active ones, being much more potent than Ketoconazole and reaching the activity of Abiraterone. However, they were not very selective. Another rather potent and more selective inhibitor (compound 23, IC50 = 345 nM) was further examined in rats regarding plasma testosterone levels and pharmacokinetic properties. Compared to the reference Abiraterone, 23 was more active in vivo, showed a longer plasma half-life (10 h) and a higher bioavailability. Using our CYP17 homology protein model, docking studies with selected compounds were performed to study possible interactions between inhibitors and amino acid residues of the active site.

Catalytic asymmetric epoxidation

The present invention relates to the synthesis of chiral epoxides via a catalytic asymmetric oxidation of olefins. Additionally, the methodology provides a method of asymmetrically oxidizing sulfides and phosphines. This asymmetric oxidation employs a catalyst system composed of a metal and a chiral bishydroxamic acid ligand, which, in the presence of a stoichiometric oxidation reagent, serves to asymmetrically oxidize a variety of substrates.

Benzylphosphonic acid inhibitors of human prostatic acid phosphatase

A series of α-substituted benzylphosphonic acids is described as inhibitors of human prostatic acid phosphatase, an enzyme has been used as a model to study aryl phosphatases. The most potent inhibitors in this series are 2-trifluoromethylbenzhydrylphosphonic acid (9 μM), and α-(2-phenylethyl)benzylphosphonic acid (14 μM). The structure-activity studies suggest that bulk tolerance beyond the phosphate binding area limits the steric or hydrophobic contribution to inhibitor potency achieved through α-carbon substitution.

Clathrate Formers with Allene Structure - Host Compounds, Crystal Inclusion and Structure of a Dioxane Clathrate

The tetraaryl-substituted allenes 1-8 are synthesized, and their properties in crystal inclusion are determined.Dependent on the type and number of the substituents, host compounds result, which have different inclusion properties and clathrate selectivities.Host 1h forms inclusion compounds with a wide range of apolar and relatively polar cyclic guest solvents (26 inclusions altogether), while 2, 4, 5, and 7b form only one or two inclusions.In two-component solvent systems, high inclusion selectivities are found for the host compounds.The crystal structure of the4*dioxane (1:1) clathrate is reported.Relations between structure and inclusion selectivity are discussed.