77358-87-3Relevant academic research and scientific papers
THERAPEUTIC AGENT FOR DIABETES
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, (2008/06/13)
A therapeutic agent for diabetes, which comprises a compound of the formula [I] wherein Xis a group of the formula wherein R4and R5are the same or different and each is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, and R6is a hydrogen atom or an amino-protecting group; R1is an optionally substituted alkyl having 1 to 5 carbon atoms, an optionally substituted alkenyl having 2 to 6 carbon atoms and the like, R2is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, R2' is a hydrogen atom, and R3is an optionally substituted alkyl having 1 to 5 carbon atoms and the like, a prodrug thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof and a solvate thereof. The compound of the present invention shows superior blood sugar decreasing action on the state of hyperglycemia, but does not affect the blood sugar when it is in the normal range or in the hypoglycemic state, which means that it is free of serious side effects such as hypoglycemia. Therefore, the compound of the present invention is useful as a therapeutic drug for diabetes and also useful as a preventive of the chronic complications of diabetes.
Addition of Aldehydes to Activated Double Bonds, XXVIII. Preparations and Reactions of Alkoxy- and Acetoxy-2,5-diones
Stetter, Hermann,Mohrmann, Karl-Heinrich,Schlenker, Walter
, p. 581 - 596 (2007/10/02)
Thiazolium salt-catalyzed addition of aliphatic ether-aldehydes and pyrancarbaldehydes leads to corresponding 1-alkoxy-2,5-alkanediones 1-11 and pyranyl-1,4-alkanediones 28 - 47.In the same manner aldehydes react with 1-acetoxy-3-buten-2-one to give 1-acetoxy-2,5-alkanediones 12 - 19, which after saponification yield the 1-hydroxy-5-alkyl-2,5-pentanediones 20 - 27.
