77362-24-4 Usage
Uses
Used in Pharmaceutical Research:
(4Z)-4-[(1-acetyl-1H-indol-3-yl)methylidene]-2-phenyl-1,3-oxazol-5(4H)-one is used as a building block in pharmaceutical research for the synthesis of complex molecules. Its structural diversity and potential biological activities make it a valuable compound for the development of new drugs.
Used in Organic Synthesis:
In the field of organic synthesis, (4Z)-4-[(1-acetyl-1H-indol-3-yl)methylidene]-2-phenyl-1,3-oxazol-5(4H)-one is used as an intermediate to create a variety of complex organic molecules. Its unique structure allows for the formation of new compounds with potential applications in various industries.
Used in Drug Discovery:
(4Z)-4-[(1-acetyl-1H-indol-3-yl)methylidene]-2-phenyl-1,3-oxazol-5(4H)-one is used as a potential candidate in drug discovery due to its structural diversity and potential biological activities. Researchers are exploring its properties to identify new therapeutic agents for various medical conditions.
Used in Material Science:
In the field of material science, (4Z)-4-[(1-acetyl-1H-indol-3-yl)methylidene]-2-phenyl-1,3-oxazol-5(4H)-one is used in the development of new materials. Its unique properties may contribute to the creation of advanced materials with specific characteristics for various applications.
Used in Organic Electronics:
(4Z)-4-[(1-acetyl-1H-indol-3-yl)methylidene]-2-phenyl-1,3-oxazol-5(4H)-one is also used in the development of organic electronics. Its electronic properties may be harnessed to create novel electronic devices and components with improved performance and functionality.
Check Digit Verification of cas no
The CAS Registry Mumber 77362-24-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,3,6 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 77362-24:
(7*7)+(6*7)+(5*3)+(4*6)+(3*2)+(2*2)+(1*4)=144
144 % 10 = 4
So 77362-24-4 is a valid CAS Registry Number.
77362-24-4Relevant academic research and scientific papers
Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails
Awadallah, Fadi M.,Bua, Silvia,Mahmoud, Walaa R.,Nada, Hossam H.,Nocentini, Alessio,Supuran, Claudiu T.
, p. 629 - 638 (2018/03/26)
Being the primary sulfonamide among the most efficient zinc binding group (ZBG) to design inhibitors for the metallo-enzymes carbonic anhydrases (CA, EC 4.2.1.1), herein, we propose an investigation on four physiologically important human (h) CAs (hCA I, II, IV, and IX) with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails. The effect of the functionalisation of the sulfonamide group with five different substitution patterns, namely acetyl, pyridine, thiazole, pyrimidine, and carbamimidoyl, was evaluated in relation to the inhibition profile of the corresponding primary sulfonamide analogues. With most of these latter being nanomolar inhibitors of all four considered isoforms, a totally counterproductive effect on the inhibition potency can be ascribed to N1-functionalisations of the ZBG primary sulfonamide structure with pyridine, thiazole, and pyrimidine moieties. On the other hand, incorporation of less hindered groups, such as sulfonylacetamides and sulfonylguanidines, maintained a certain degree of activity dependent on the tailing moiety, with KIs spanning in the low micromolar range.
