77367-05-6

Basic information

• Product Name: 2-Chloro-N-[2-hydroxy-5-(1-methyl-cyclopentyl)-benzyl]-acetamide
• Synonyms: 2-Chloro-N-[2-hydroxy-5-(1-methyl-cyclopentyl)-benzyl]-acetamide
• CAS NO: 77367-05-6
• Molecular Weight: 281.782
• Mol File: 77367-05-6.mol

Chemical Properties

• CAS DataBase Reference: 2-Chloro-N-[2-hydroxy-5-(1-methyl-cyclopentyl)-benzyl]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-N-[2-hydroxy-5-(1-methyl-cyclopentyl)-benzyl]-acetamide(77367-05-6)
• EPA Substance Registry System: 2-Chloro-N-[2-hydroxy-5-(1-methyl-cyclopentyl)-benzyl]-acetamide(77367-05-6)

Safety Data

• Hazardous Substances Data: 77367-05-6(Hazardous Substances Data)

Upstream product

• 2832-19-1 2-Chloro-N-(hydroxymethyl)acetamide 
• 1562-25-0 4-(1-methylcyclopentan-1-yl)phenol 

Downstream Products

• 75551-97-2 2-Aminomethyl-6-iodo-4-(1-methyl-cyclopentyl)-phenol; hydrochloride 
• 75552-25-9 2-(aminomethyl)-4-(1-methylcyclopentyl)phenol hydrochloride 

Relevant articles and documents

2-(Aminomethyl)phenols, a new class of saluretic agents. I. Effect of nuclear substitution

A series of 2-(aminomethyl)phenols was synthesized and tested in rats and dogs for saluretic and diuretic activity. A number of these compounds exhibit a high order of activity on iv or po administration. The most active compounds belong to a subseries of 4-alkyl-6-halo derivatives of which 2,2(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenyl, is the most active. Compound 2 also possesses significant antihypertensive activity, an adjunctive pharmacological parameter which distinguishes 2 from the other compounds prepared in this series. In addition, 2 displays both topical saluretic and antiinflammatory activities.