77376-62-6

Upstream product

• 3147-39-5 methyl 2,4,6-trihydroxybenzoate 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 

Downstream Products

• 77376-63-7 methyl 4,6-bisbenzyloxy-2-(9-hydroxynonyloxy)benzoate 
• 205056-73-1 methyl 2,4-dibenzyloxy-6-trifluoromethanesulfonyloxybenzoate 
• 77376-64-8 4,6-bisbenzyloxy-2-(9-hydroxynonyloxy)benzoic acid 
• 77376-65-9 4,6-bisbenzyloxy-2-(9-hydroxynonyloxy)benzoic acid lactone 
• 205056-75-3 (S)-5,7-dibenzyloxy-3-(1-acetyl)phthalide 
• 205056-71-9 (R)-5,7-dibenzyloxy-3-(1-acetyl)phthalide 
• 205056-74-2 (3S,1S)-5,7-dibenzyloxy-3-(1-hydroxyethyl)phthalide 
• 205056-70-8 (3R,1R)-5,7-dibenzyloxy-3-(1-hydroxyethyl)phthalide 
• 63604-98-8 1,3-dibenzylphloroglucinol 

Relevant academic research and scientific papers

Syntheses and bioactivities of acetophthalidin and its derivatives

Acetophthalidin is a potent cell cycle inhibitor which was isolated from a fungal strain. Both enantiomers of acetophthalidin and its derivatives were synthesized, and their bioactivities were examined.

Synthesis of both enantiomers of acetophthalidin

Both enantiomers of acetophthalidin, a potent cell cycle inhibitor, were synthesized employing Sharpless asymmetric dihydroxylation as a key step.

Synthesis of Oxa-analogues of Zearalanone

The synthesis of macrocyclic lactones related to zearalanone is described. The reaction of salicylic acids with 1,9-dibromononane, 1,9-dichloro-5-oxanonane, and 1,9-dibromononan-5-one was used to prepare the corresponding lactones.Cyclisation of 2-(9-hydroxynonyloxy)benzoic acid, 4,6-dibenzyloxy-2-(9-hydroxynonyloxy)benzoic acid, and 4-benzyloxy-2-hydroxy-6-(9-hydroxy-5-oxodecyloxy)benzoic acid using diethyl azodicarboxylate-triphenylphosphine gave the corresponding lactones in moderate yield.