77378-05-3

Usage

Uses

A novel labelled N6-substituted Cordycepin derivative; an adenosine deaminase inhibitor.

InChI:InChI=1/C18H27N5O4/c1-2-3-4-5-6-7-14(26)22-16-15-17(20-10-19-16)23(11-21-15)18-13(25)8-12(9-24)27-18/h10-13,18,24-25H,2-9H2,1H3,(H,19,20,22,26)/t12-,13?,18+/m0/s1

Upstream product

• 73-03-0 cordycepin 
• 111-64-8 n-octanoic acid chloride 
• 116285-72-4 9-((2R,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-9H-purin-6-amine 
• 865853-43-6 (3R,5S)-5-(methylacetoxytetrahydrofuran)-2,3-diyl diacetate 
• 222055-48-3 1,2-O-isopropylidene-D-xylofuranose 
• 20881-04-3 1,2,3,5-di-O-isopropylidene-D-xylofuranose 
• 71196-28-6 ((2S,4R,5R)-4-acetoxy-5-(6-amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl acetate 

Relevant academic research and scientific papers

ADENOSINE ANALOG AND ITS USE IN REGULATING THE CIRCADIAN CLOCK

Provided are a kind of nucleoside analogue compounds, and compositions comprising these compounds and pentostatin, their use for modulating circadian rhythm, preferably, for shifting circadian phase, and methods for modulating circadian rhythm, preferably, for shifting circadian phase via these compounds or the compositions.

Synthesis and pharmacokinetic evaluation of novel N-acyl-cordycepin derivatives with a normal alkyl chain

For slowing down the too fast metabolic velocity and increasing the bioavailability of cordycepin, four N-acyl-(propionyl-, octanoyl-, lauroyl- and stearoyl-) cordycepin derivatives were synthesized chemically and their pharmacokinetic profiles were inves