77378-54-2

Usage

Uses

Used in Organic Synthesis:
2-(BromoMethyl)-1-Methyl-3-nitrobenzene is used as a key intermediate in the synthesis of various organic compounds for different applications. Its unique structure, containing bromine, nitro, and methyl groups, allows for versatile chemical reactions, making it a valuable building block in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(BromoMethyl)-1-Methyl-3-nitrobenzene is used as a starting material for the synthesis of various drug molecules. Its reactivity and functional groups enable the development of new drugs with potential therapeutic benefits. The bromine atom can be replaced with other functional groups, while the nitro group can be reduced to form amines, which are common in many pharmaceutical compounds.
Used in Agrochemical Industry:
2-(BromoMethyl)-1-Methyl-3-nitrobenzene is also utilized in the agrochemical industry for the synthesis of pesticides and other crop protection agents. Its chemical properties allow for the creation of compounds with effective pest control properties, contributing to increased crop yields and improved agricultural productivity.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 2-(BromoMethyl)-1-Methyl-3-nitrobenzene is used as a precursor for the synthesis of various dyes and pigments. Its ability to undergo different chemical reactions enables the production of a wide range of colors and shades, which are used in various applications such as textiles, plastics, and printing inks.
Used in Research and Development:
2-(BromoMethyl)-1-Methyl-3-nitrobenzene is also employed in research and development laboratories for the study of new chemical reactions and the development of novel synthetic routes. Its unique structure and reactivity make it an interesting compound for chemists to explore and understand the underlying mechanisms of various chemical transformations.

Upstream product

• 83-41-0 2,3-dimethylnitrobenzene 
• 66126-16-7 1,2-bis(bromomethyl)-3-nitrobenzene 
• 54915-41-2 2-(hydroxymethyl)-3-methyl-1-nitrobenzene 
• 66232-57-3 2-methyl-6-nitrobenzoyl chloride 

Downstream Products

• 146667-90-5 6-methyl-2-nitrostyrene 
• 85062-48-2 3-(4-Methoxy-benzyl)-5-methyl-3,4-dihydro-quinazolin-2-ylamine; hydrobromide 
• 85062-68-6 4-(4-Methoxy-benzyl)-6-methyl-4,5-dihydro-imidazo[1,2-a]quinazolin-2-one; hydrochloride 
• 872323-59-6 diethyl (acetylamino)(2-methyl-6-nitrobenzyl)malonate 
• 1290617-48-9 tert-butyl N-(diphenylmethylidene)-2-methyl-6-nitro-L-phenylalaninate 
• 134541-57-4 1-Methyl-3-nitro-2-prop-2-ynyloxymethyl-benzene 

Relevant academic research and scientific papers

METHOD FOR PRODUCING 2-(HALOGENOMETHYL)-3-METHYLNITROBENZENE

Position-1 halogen can be selectively reduced by reacting a compound represented by formula (3): [wherein X represents a chlorine atom, a bromine atom, or an iodine atom] with halogen in the presence of a heterogeneous transition metal catalyst to produce 2-(halogenomethyl)-1-methyl-3-nitrobenzene represented by formula (1): [wherein the symbol is as defined above].

TETRAZOLINONE COMPOUNDS AND APPLICATIONS THEREOF

A tetrazolinone compound represented by formula (1): wherein Q represents a 6-membered aromatic heterocyclic group optionally having one or more atoms or groups selected from Group P1, provided that a heteroatom constituting the heterocyclic gr

TETRAZOLINONE COMPOUND AND USE THEREOF

The compound represented by formula (1): wherein R4 and R5 each represents a hydrogen atom, a halogen atom, or a C1-C3 alkyl group; R6 represents a C1-C4 alkyl group, a C3-C6 cycloalkyl group, or the like; R7, R8, and R9 each represents a hydrogen atom, a halogen atom, or the like; R10 represents a C1-C3 alkyl group, or the like; R13 represents a C1-C3 alkyl group, or the like; and Q represents a phenyl group, or the like; has an excellent control effect on pests.

TETRAZOLINONE COMPOUNDS AND ITS USE AS PESTICIDES

The present invention provides a compound having an excellent efficacy for controlling pests. A tetrazolinone compound of a formula (1): [wherein R1 represents an C6-C16 aryl group, an C1-C12 alkyl group, or a C3-C12 cycloalkyl group, etc., which each optionally be substituted; R2, R3, R4 and R5 represent independently of each other a hydrogen atom, a halogen atom or an C1-C3 alkyl group, etc.; R6 represents an C1-C6 alkyl group, a C3-C6 cycloalkyl group, a halogen atom, a C1-C6 haloalkyl group, an C2-C6 alkenyl group, an C1-C6 alkoxy group, or a C1-C6 haloalkoxy group, etc.; R7, R8 and R9 represent independently of each other a hydrogen atom, a halogen atom, or an C1-C4 alkyl group, etc.; X represents an oxygen atom or a sulfur atom; and R10 represents an C1-C6 alkyl group, etc.] shows an excellent controlling efficacy on pests.

A general strategy for the synthesis of cyclic N-aryl hydroxamic acids via partial nitro group reduction

We describe a generalized approach to stereocontrolled synthesis of substituted cyclic hydroxamic acids (3-amino-1-hydroxy-3,4-dihydroquinolinones) by selective reduction of substituted 2-nitrophenylalanine substrates. Compounds in this series have antibacterial properties and have also recently been reported as KAT II inhibitors. The key nitrophenyl alanine intermediates are prepared enantioselectively in excellent yield by phase transfer catalyzed alkylation of the corresponding nitrobenzyl bromides. The scope and limitations of the reductive cyclization transformation have been explored with attention to the effects of substitution pattern and electronics on reaction efficiency and byproduct formation. In addition, a novel activated trifluoroethyl ester cyclization strategy has been developed as an alternate approach to the most sterically demanding systems in this series.

Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors

Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase that plays a critical role in the early development of the nervous system. Deregulation of CDK5 is believed to contribute to the abnormal phosphorylation of various cellular substrates associated with neurodegenerative disorders such as Alzheimer's disease, amyotrophic lateral sclerosis, and ischemic stroke. Acyclic urea 3 was identified as a potent CDK5 inhibitor and co-crystallographic data of urea 3/CDK2 enzyme were used to design a novel series of 3,4-dihydroquinazolin-2(1H)-ones as CDK5 inhibitors. In this investigation we present our synthetic studies toward this series of compounds and discuss their biological relevance as CDK5 inhibitors.

INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2

This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLAα). In some embodiments, the inhibitors have the Formula I: wherein the constituent variables are as defined herein.

2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use

Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

o-Nitroaryldioxolane for protection of pheromones. Study of the photodelivery of carbonylic compounds

o-Nitrophenyldioxolanes 1 to 12 have been prepared and the rate of their photocleavage determined Steric congestion in the molecule causes a decrease of the reaction rate. The decrease in the rate is especially important in the presence of a nitro group in a second phenyl ring.