7738-22-9

Basic information

• Product Name: BOC-SER(TBU)-OH
• Synonyms: BOC-L-SER(TBU)-OH;BOC-O-T-BUTYL-L-SERINE;BOC-SER(BU)-OH;BOC-SER(BUT)-OH;BOC-SER(TBU)-OH;BOC-SER-OTBU;BOC-SERINE(TBU)-OH;N-ALPHA-TERT-BUTYLOXYCARBONYL-O-TERT-BUTYL-L-SERINE
• CAS NO: 7738-22-9
• Molecular Formula: C₁₂H₂₃NO₅
• Molecular Weight: 261.31
• Mol File: 7738-22-9.mol
• Article Data: 26

Chemical Properties

• Melting Point: 80℃
• Boiling Point: 381.9±32.0 °C(Predicted)
• Appearance: /
• Density: 1.087±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.70±0.46(Predicted)
• CAS DataBase Reference: BOC-SER(TBU)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-SER(TBU)-OH(7738-22-9)
• EPA Substance Registry System: BOC-SER(TBU)-OH(7738-22-9)

Safety Data

• Hazardous Substances Data: 7738-22-9(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

(S)-tert-Butyl 2-((tert-Butoxycarbonyl)amino)-3-hydroxypropanoate has been used as a reactant in the synthesis of biomembrane-mimic polymers for tissue engineering or bioimplants.

Upstream product

• 847373-29-9 O-tert-butyl-N,N'-diisopropylurea 
• 3262-72-4 (S)-N-(tert-butoxycarbonyl)serine 
• 507-20-0 tertiary butyl chloride 
• 59859-77-7 2-benzyloxycarbonylamino-3-hydroxy-propionic acid tert-butyl ester 
• 507-19-7 t-butyl bromide 
• 71432-55-8 2-tert-butyl-1,3-diisopropylisourea 
• 75-65-0 tert-butyl alcohol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 
• 23680-31-1 BOC-O-benzyl-L-serine 
• 3587-60-8 Benzyloxymethyl chloride 
• 81477-94-3 N-(diphenylmethylene)glycine tert-butyl ester 
• 95319-02-1 N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-L-serine 1,1-dimethylethyl ester 
• 90048-49-0 tert-butyl (2S)-2-amino-3-hydroxypropanoate 

Downstream Products

• 1039749-86-4 C₆₂H₉₆NO₁₂PS 
• 312-84-5 D-Serine 
• 56-45-1 L-serin 
• 107082-54-2 N-(tert-butyloxycarbonyl)-α,β-dehydroalanine tert-butyl ester 
• 108492-14-4 tert-butyl (S)-3-azido-2-((tert-butoxycarbonyl)amino)propanoate 
• 944064-68-0 O-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)-(1->3)-(4-O-benzyl-2-deoxy-2-nitro-6-(triisopropylsilyl)-α-D-galactopyranosyl)-N-(tert-butyloxycarbonyl)-L-serine tert-butyl ester 
• 944065-05-8 O-(3,4-di-O-benzyl-6-O-(tert-butyldiphenylsilyl)-2-deoxy-2-nitro-α-D-galactopyranosyl)-(1->3)-(4-O-acetyl-2-deoxy-2-nitro-6-O-(triisopropylsilyl)-α-D-galactopyranosyl)-N-(tert-butyloxycarbonyl)-L-serine tert-butyl ester 
• 944064-95-3 O-(2-azido-2-deoxy-3,4,6-tri-O-benzyl-β-D-glucopyranosyl)-(1->6)-3,4-di-O-benzyl-2-deoxy-2-nitro-D-galactopyranosyl)-N-(t-butyloxycarbonyl)-L-serine tert-butyl ester 
• 944064-81-7 O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->3)-(di-4,6-O-benzyl-2-nitro-2-deoxy-α-D-galactopyranosyl)-N-(t-butyloxycarbonyl)-L-serine tert-butyl ester 
• 944064-83-9 O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->3)-(4-O-benzyl-2-nitro-2-deoxy-6-O-(triisopropylsilyl)-α-D-galactopyranosyl)-N-(t-butyloxycarbonyl)-L-serine tert-butyl ester 

Relevant articles and documents

Zirconium-Catalyzed Hydroalumination of C=O Bonds: Site-Selective De- O-acetylation of Peracetylated Compounds and Mechanistic Insights

An unprecedented hydroalumination of C = O bonds catalyzed by zirconocene dichloride is reported herein and applied to the site-selective deprotection of peracetylated functional substrates. A mixed metal hydride, with 1:1 zirconium/aluminum stoichiometry

Non-naturally Occurring Regio Isomer of Lysophosphatidylserine Exhibits Potent Agonistic Activity toward G Protein-Coupled Receptors

Lysophosphatidylserine (LysoPS), an endogenous ligand of G protein-coupled receptors, consists of l-serine, glycerol, and fatty acid moieties connected by phosphodiester and ester linkages, respectively. An ester linkage of phosphatidylserine can be hydrolyzed at the 1-position or at the 2-position to give 2-acyl lysophospholipid or 1-acyl lysophospholipid, respectively. 2-Acyl lysophospholipid is in nonenzymatic equilibrium with 1-acyl lysophospholipid in vivo. On the other hand, 3-acyl lysophospholipid is not found, at least in mammals, raising the question of whether the reason for this might be that the 3-acyl isomer lacks the biological activities of the other isomers. Here, to test this idea, we designed and synthesized a series of new 3-acyl lysophospholipids. Structure-activity relationship studies of more than 100 "glycol surrogate"derivatives led to the identification of potent and selective agonists for LysoPS receptors GPR34 and P2Y10. Thus, the non-natural 3-acyl compounds are indeed active and appear to be biologically orthogonal with respect to the physiologically relevant 1-and 2-acyl lysophospholipids.

L-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of L-histidine and L-tryptophan

A series of 1,2,3-triazole analogs of the amino acids L-histidine and L-tryptophan were modeled, synthesized and tested for L-type amino acid transporter 1 (LAT1; SLC7A5) activity to guide the design of amino acid-drug conjugates (prodrugs). These triazol