77383-21-2

Upstream product

• 201230-82-2 carbon monoxide 
• 101-83-7 N-cyclohexyl-cyclohexanamine 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 78141-09-0 (2S,3S)-2,3-Diphenyl-pentanedioic acid 1-dicyclohexylamide 5-dimethylamide 
• 78141-09-0 (2S,3R)-2,3-Diphenyl-pentanedioic acid 1-dicyclohexylamide 5-dimethylamide 
• 155242-20-9 N,N-Dicyclohexyl-2-phenyl-thioacetamide 
• 78141-07-8 (3S,4S)-4-Dicyclohexylcarbamoyl-3,4-diphenyl-butyric acid methyl ester 
• 78141-07-8 (3R,4S)-4-Dicyclohexylcarbamoyl-3,4-diphenyl-butyric acid methyl ester 
• 96767-56-5 α-(4-Chlorbenzyl)-phenylessigsaeure-N,N-dicyclohexylamid 

Relevant academic research and scientific papers

Charge-Transfer Complex Promoted C-N Bond Activation for Ni-Catalyzed Carbonylation

A new strategy was developed for activation of C-N bond via formation of an amine-I2 charge-transfer complex, which facilitates the inert C-N bond activation via oxidative addition with Ni(0). This strategy has been successfully applied in the Ni-catalyzed carbonylation of benzylamines via direct insertion of CO into the C-N bond, which provided a straightforward and rapid approach to arylacetamides in the presence of catalytic amounts of I2 and Ni catalyst. Mechanistic studies suggested that a benzyl radical generated via the oxidative addition was involved in the present reaction.