77384-89-5Relevant academic research and scientific papers
Benzhydryl as an efficient selective nitrogen protecting group for uracils
Wu, Fan,Buhendwa, Musole G.,Weaver, Donald F.
, p. 9307 - 9309 (2007/10/03)
Regioselective N-substitution of the less active nitrogen within uracil analogues has been achieved following preliminary N-protection at the more active N-position with a benzhydryl protecting group. This protecting group is stable to concentrated HCl (a
Application of the Benzyloxycarbonyloxymethyl Moiety to a Protective Group of 5-Fluoroacil. Selective Alkylation of Amide Nitrogen of the Uracil Ring
Nagase, Toshio,Seike, Kanzo,Shiraishi, Kazuto,Yamada, Yutaka,Ozaki, Shoichiro
, p. 1381 - 1384 (2007/10/02)
Selective alkylation of 5-fluorouracil using the benzoyloxycarbonyloxymethyl moiety as a protective group of amide nitrogen of the uracil ring is described.Protection, alkylation and deprotection were carried out in high yields.
A NOVEL ROUTE TO 5-FLUOROURACILS FROM CHLOROTRIFLUOROETHENE
Fuchikami, Takamasa,Yamanouchi, Akiko,Suzuki, Yasuyuki
, p. 1573 - 1576 (2007/10/02)
Diethyl fluoromalonate was prepared in one-pot from chlorotrifluoroethene via trifluoroacrylic acid lithium salt in 79percent yield.Diethyl fluoromalonate was easily converted to 5-fluoro-6-chlorouracils, reductions of which gave 5-fluorouracils in good yields.
5-FLUOROURACIL DERIVATIVES. VI. ALKYLATION OF 5-FLUOROURACIL USING THE (OCTYLTHIO)CARBONYL GROUP AS A PROTECTING FUNCTION
Ozaki, Shoichiro,Watanabe, Yutaka,Fujisawa, Hiroshi,Hoshiko, Tomonori
, p. 527 - 530 (2007/10/02)
N1- and N3-alkyl-5-fluorouracils are prepared in good yields by the alkylation of 5-fluorouracil protected by the (octylthio)carbonyl group.
