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Usage

Uses

Used in Pharmaceutical Industry:
DIETHYL MALONATE (1,3-13C2) is used as a key intermediate in the preparation of barbiturates, which are central nervous system depressants used for inducing sleep, sedation, or anesthesia.
Used in Flavoring Industry:
DIETHYL MALONATE (1,3-13C2) is used as a precursor in the synthesis of artificial flavorings, enhancing the taste and aroma of various food products.
Used in Vitamin Production:
DIETHYL MALONATE (1,3-13C2) is used as a starting material in the production of vitamin B1 (thiamine) and vitamin B6 (pyridoxine), which are essential for various metabolic processes in the human body.
Used in Perfumery:
DIETHYL MALONATE (1,3-13C2) is used as a component in the creation of perfumes, contributing to the unique scents and fragrances of various products.
Used in Streptothricin Preparation:
DIETHYL MALONATE (1,3-13C2) is used as a precursor in the preparation of streptothricin, an antibiotic used in veterinary medicine to treat bacterial infections.
Used in Labeled Fatty Acids Production:
DIETHYL MALONATE (1,3-13C2) is used in the synthesis of labeled fatty acids, which are important for research purposes, particularly in studying metabolic pathways and the effects of various compounds on lipid metabolism.

Upstream product

• 64-17-5 ethanol 
• 1111-72-4 carbon dioxide 
• 83335-57-3 2-(trimethylsilyl)-<1-(13)C>acetic acid 

Downstream Products

• 67519-32-8 2-<1-(13C)-Phenethyl>-1.3-<13C>-malonsaeure-diethylester 
• 1644306-10-4 C₁₄⁽¹³⁾C₂H₁₈O₄ 
• 1202222-10-3 C₇⁽¹³⁾C₂H₁₀O₃ 
• 88596-93-4 C₁₃⁽¹³⁾C₂H₁₅NO₆ 
• 102088-01-7 1,3-¹³C₂-glycerol 

Relevant academic research and scientific papers

Synthesis of an Isotopically Isomeric Mixture of 1,4,6,8-Tetramethyl2>azulene and Its Thermal Reaction with Dimethyl Acetylenedicarboxylate

Sodium 2>cyclopentadienide in tetrahydrofuran (THF) has been prepared from the corresponding labelled 2>cyclopentadiene which was synthesized from 13CO2 and (chloromethyl)trimethylsilane (cf.Scheme 10) according to an established procedure.It could be shown that the acetate pyrolysis of cis-cyclopentane-1,2-diyl diacetate (cis-22) at 550 +/- 5 deg under reduced pressure (60 Torr) gives five times as much cyclopentadiene as trans-22.The reaction of sodium 2>cyclopentadienide with 2,4,6-trimethylpyrylium tetrafluoroborate in THF leads to the formation of the statistically expected 2:2:1 mixture of 4,6,8-trimethyl2>-, -2>-, and -2>azulene (20; cf.Scheme 7 and Fig. 1).Formylation and reduction of the 2:2:1 mixture 2>-20 results in the formation of a 1:1:1:1:1 mixture of 1,4,6,8-tetramethyl2>-, -2>-, -2>-, -2>-, and -2>azulene (5; cf.Scheme 8 and Fig. 2).The measured 2J(13C,13C) values of 2>-20 and 2>-5 are listed in Tables 1 and 2.Thermal reaction of the 1:1:1:1:1 mixture 2>-5 with the four-fold amound of dimethyl acetylenedicarboxylate (ADM) at 200 deg in tetralin (cf.Scheme 2) gave 5,6,8,10-tetramethyl-2>heptalene-1,2-dicarboxylate (2>-6a; 22percent), its double-bond-shifted (DBS) isomer 2>-6b (19percent), and the corresponding azulene-1,2-dicarboxylate 7 (18percent).The isotopically isomeric mixture of 2>-6a showed no 1J(13C,13C) at C(5) (cf.Fig. 3).This finding is in agreement with the fact that expected primary tricyclic intermediate 2>-8 exhibits at 200 deg in tetralin only cleavage of the C(1)-C(10) bond and formation of a C(7)-C(10) bond (cf.Schemes 6 and 9), but no cleavage of the C(1)-C(11) bond and formation of a C(7)-C(11)-bond.The limits of detection of the applied method is Y>/= 96percent for the observed process, i.e., 2>-5 + ADM -> 2>-8 -> 2>-9 -> 2>-6a (cf.Scheme 6).