773873-26-0

Basic information

• Product Name: 2,3-DIFLUORO-4-METHOXYBENZOIC ACID
• Synonyms: 2,3-Difluoro-4-methoxylbenzoic acid;2,3-Difluoro-6-methoxybenzoic acid
• CAS NO: 773873-26-0
• Molecular Formula: C₈H₆F₂O₃
• Molecular Weight: 188.13
• Product Categories: Aromatic Halides (substituted);Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid
• Mol File: 773873-26-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 126-129°C
• Boiling Point: 275 °C at 760 mmHg
• Flash Point: 120.1 °C
• Appearance: /
• Density: 1.399 g/cm³
• Vapor Pressure: 0.00254mmHg at 25°C
• Refractive Index: 1.504
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.82±0.10(Predicted)
• CAS DataBase Reference: 2,3-DIFLUORO-4-METHOXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIFLUORO-4-METHOXYBENZOIC ACID(773873-26-0)
• EPA Substance Registry System: 2,3-DIFLUORO-4-METHOXYBENZOIC ACID(773873-26-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 773873-26-0(Hazardous Substances Data)

Usage

Description

2,3-DIFLUORO-4-METHOXYBENZOIC ACID is a chemical compound with the formula C8H6F2O3, belonging to the benzoic acid derivatives. It features two fluorine atoms and one methoxy group, contributing to its unique chemical properties. This white crystalline solid has a melting point of approximately 118-120°C and exhibits limited solubility in water. Due to its potential to cause irritation to the skin, eyes, and respiratory system, careful handling is advised.

Uses

Used in Pharmaceutical Industry:
2,3-DIFLUORO-4-METHOXYBENZOIC ACID is utilized as a building block in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, making it a valuable component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2,3-DIFLUORO-4-METHOXYBENZOIC ACID serves as a key intermediate in the production of pesticides and other agrochemicals. Its incorporation can enhance the effectiveness of these products and contribute to agricultural productivity.
Used in Specialty Chemicals Production:
2,3-DIFLUORO-4-METHOXYBENZOIC ACID is also employed as an intermediate in the manufacturing of specialty chemicals. Its distinctive chemical characteristics enable the creation of high-value compounds for use in various industries, such as materials science and coatings.

InChI:InChI=1/C8H6F2O3/c1-13-5-3-2-4(9)7(10)6(5)8(11)12/h2-3H,1H3,(H,11,12)

Upstream product

• 1017576-43-0 2,3-difluoro-6-methoxyphenyllithium 
• 124-38-9 carbon dioxide 
• 187543-87-9 2,3-difluoro-6-methoxybenzaldehyde 

Relevant articles and documents

Preparation method for 2, 3-difluoro-6-methoxy benzoic acid

The invention provides a preparation method for 2, 3-difluoro-6-methoxy benzoic acid. The preparation method includes the steps: (1) preparing tetrahydrofuran solution of lithium diisopropylamide; (2) reducing temperature to range from -75 DEG C to -65 DE

PYRAZOLE DERIVATIVES FOR THE INHIBITION OF CDK' S AND GSK' S

The invention provides compounds of the formula (I), or salts, tautomers, N-oxides or solvates thereof wherein: R1 is selected from: (a) 2,6-dichlorophenyl; (b) 2,6-difluorophenyl; (c) a 2,3,6-trisubstituted phenyl group wherein the substituents for the phenyl group are selected from fluorine, chlorine, methyl and methoxy; (d) a group R0; (e) a group R a; (f) a group Rlb; (g) a group Rlc; (h) a group Rld; and 0) 2,6-difluorophenylamino ; wherein R )0υ, r R> llaa, T Rj I1bD, T R) I1cC, r R> Iidα, r R?2zaa, r R>22bD and RJ are as defined in the claims. The compounds have activity as inhibitors of cdk kinase (such as cdkl or cdk2) and glycogen synthase kinase-3 activity.