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Usage

Uses

Used in Pharmaceutical Industry:
[1,1'-Biphenyl]-3-carboxylic acid, 4'-(trifluoroMethyl)-, Methyl ester is used as a building block for the synthesis of various pharmaceutical compounds due to its unique structure and reactivity. The trifluoromethyl group's ability to improve lipophilicity and bioavailability makes it a desirable modification in drug design, potentially leading to more effective medications.
Used in Organic Synthesis:
In the field of organic synthesis, [1,1'-Biphenyl]-3-carboxylic acid, 4'-(trifluoroMethyl)-, Methyl ester serves as an intermediate for creating diverse molecular scaffolds. Its specific reactivity allows for the development of a wide range of chemical products, contributing to the advancement of material science and chemical research.
Used in Medicinal Chemistry:
[1,1'-Biphenyl]-3-carboxylic acid, 4'-(trifluoroMethyl)-, Methyl ester is utilized in medicinal chemistry as a key intermediate for the preparation of potential drug candidates. Its unique structural features and the trifluoromethyl group's influence on bioavailability make it an important component in the development of new therapeutic agents.

Upstream product

• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 618-95-1 methyl 3-nitrobenzoate 
• 6725-72-0 4-methoxycarbonylbenzoic acid phenyl ester 
• 7377-26-6 4-Methoxycarbonylbenzoyl chloride 
• 2905-65-9 methyl 3-chlorobenzoate 
• 98-56-6 4-chlorobenzotrifluoride 

Relevant academic research and scientific papers

The Suzuki-Miyaura Coupling of Nitroarenes

Synthesis of biaryls via the Suzuki-Miyaura coupling (SMC) reaction using nitroarenes as an electrophilic coupling partners is described. Mechanistic studies have revealed that the catalytic cycle of this reaction is initiated by the cleavage of the aryl-nitro (Ar-NO2) bond by palladium, which represents an unprecedented elemental reaction.

Nickel-Catalyzed Decarbonylative Coupling of Aryl Esters and Arylboronic Acids

A variety of functionalized biaryls can be accessed by coupling aryl and heteroaryl esters with boronic acids in Suzuki-Miyaura-type decarbonylative cross-coupling catalyzed by an affordable catalyst system composed of Ni(cod)2 and PCy3. The methodology is tolerant of a variety of functional groups and presents an attractive alternative to the use of palladium catalysis currently used in industry to acquire such bis(hetero)aryls, but also reveals challenges associated with nickel catalysis of esters in cross-coupling chemistry.

Efficient cobalt-catalyzed formation of unsymmetrical biaryl compounds and its application in the synthesis of a sartan intermediate

(Chemical Equation Presented) No prior preparation of the organometallic reagent is required in a cobalt-catalyzed coupling of two different aryl halides under mild conditions (see scheme). A broad spectrum of valuable biaryl compounds can be prepared in this way. Not only may a variety of reactive substituents be present, but heteroaryl halides and aryl triflates are also suitable substrates. DMF = N,N-dimethylformamide, FG = functional group.